BCL10 and IL15RA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BCL10	IL15RA
Description		BCL10 immune signaling adaptor	interleukin 15 receptor subunit alpha
Image
GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Natural Killer Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Neuron Projection Development Response To Nutrient Levels Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	Interleukin-15 signaling Interleukin-15 signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Alopecia areata ( 25608926) Asthma ( 31619474 31959851) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Neuroblastoma (pediatric) ( 32599975) Soluble interleukin-2 receptor subunit alpha ( 26293465)
Interacting Genes		45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		8915	3601
HPRD ID		04625	03045
Ensembl ID		ENSG00000142867	ENSG00000134470
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		2MB9 6BZE 6GK2 8CZD 8CZO	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process	Positive Regulation Of Endocytosis Interleukin-15-mediated Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Differentiation Signal Transduction Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Transport Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Differentiation Cellular Response To Oxygen-containing Compound Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of Phagocytosis Lymphocyte Differentiation Positive Regulation Of Natural Killer Cell Differentiation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Transport Interleukin-2-mediated Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Kinase Activity Regulation Of Natural Killer Cell Differentiation T Cell Activation Regulation Of Cell Activation Positive Regulation Of Cellular Component Organization Cell Activation Transferase Activity Cellular Response To Nitric Oxide Mononuclear Cell Differentiation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Cell-cell Adhesion Positive Regulation Of B Cell Differentiation
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