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RAP1B and APLP1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
RAP1B
APLP1
Description
RAP1B, member of RAS oncogene family
amyloid beta precursor like protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Azurophil Granule Membrane
Membrane Raft
Extracellular Exosome
Anchoring Junction
Glutamatergic Synapse
Basement Membrane
Nucleoplasm
Cytoplasm
Golgi Apparatus
Plasma Membrane
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein-containing Complex Binding
Protein Binding
Heparin Binding
Alpha-2A Adrenergic Receptor Binding
Alpha-2B Adrenergic Receptor Binding
Alpha-2C Adrenergic Receptor Binding
Identical Protein Binding
Metal Ion Binding
Transition Metal Ion Binding
Biological Process
Signal Transduction
Small GTPase-mediated Signal Transduction
Cell Population Proliferation
Calcium-ion Regulated Exocytosis
Rap Protein Signal Transduction
Positive Regulation Of Integrin Activation
Negative Regulation Of Calcium Ion-dependent Exocytosis
Establishment Of Localization In Cell
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Modification Of Postsynaptic Structure
Regulation Of Cell Junction Assembly
Regulation Of Establishment Of Cell Polarity
Negative Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Translation
Endocytosis
Apoptotic Process
Cell Adhesion
Nervous System Development
Axonogenesis
Central Nervous System Development
Animal Organ Morphogenesis
Extracellular Matrix Organization
Forebrain Development
Animal Organ Development
Cellular Response To Norepinephrine Stimulus
Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Cytosolic MRNA Polyadenylation
Pathways
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Femoral neck bone mineral density (
32239398
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
HDL cholesterol levels in HIV infection (
33109212
)
White blood cell count (
20139978
)
Severe influenza A (H1N1) infection (
26379185
)
Interacting Genes
31 interacting genes:
A2M
ALAS1
APLP1
APP
CCT7
CHGB
CSAD
DDAH2
DVL2
FAF1
HRAS
KMT2B
LRIF1
MTUS2
PDHB
PKM
PRKACA
RAB7B
RALGDS
RAPGEF1
RASSF5
RGL2
RGS2
RPTOR
SDF4
SMURF2
TLE1
TP53
UNC119
ZDHHC17
ZNF135
42 interacting genes:
ANXA7
APBB1
CDK4
CDKN1A
CDKN2C
CRCT1
CSNK2B
DAB1
DAB2
EEF1A1
EIF2S2
GDF9
GSTM4
HAP1
HLA-DQA1
HSPE1
ING5
KAT5
LRIF1
MPHOSPH6
NACA
PCDHA4
PHF10
PIN1
PNP
PRNP
RAP1B
RBM48
RCC1
SAT1
SETDB1
SMN1
SNCA
STX5
TCF21
TK1
TMSB4X
TOE1
TSC22D1
UTP14A
VIM
ZNF24
Entrez ID
5908
333
HPRD ID
01546
00102
Ensembl ID
ENSG00000127314
ENSG00000105290
Uniprot IDs
B7ZAY2
P61224
P51693
PDB IDs
3BRW
3CF6
4DXA
4HDO
4HDQ
4M8N
4MGI
4MGK
4MGY
4MGZ
4MH0
5KHO
6AXF
6BA6
6KYK
6OQ3
6OQ4
6UZK
7C7I
7C7J
8SU8
8T09
8T7V
3PMR
3Q7G
3Q7L
3QMK
4RD9
4RDA
Enriched GO Terms of Interacting Partners
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Ras Protein Signal Transduction
Regulation Of Carbohydrate Catabolic Process
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Pentose-phosphate Shunt
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Regulation Of Glycolytic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Generation Of Precursor Metabolites And Energy
Small GTPase-mediated Signal Transduction
Regulation Of NADP Metabolic Process
Regulation Of JNK Cascade
Regulation Of Primary Metabolic Process
Identical Protein Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Protein Metabolic Process
Regulation Of ATP Metabolic Process
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Lipoprotein Transport
Cellular Response To Catecholamine Stimulus
Response To CAMP
Transition Metal Ion Binding
Response To Catecholamine
Regulation Of MiRNA Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Cellular Component Organization
Intracellular Signaling Cassette
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Glycolytic Process
Regulation Of Translation
Positive Regulation Of JNK Cascade
Regulation Of Nucleobase-containing Compound Metabolic Process
Molecular Function Activator Activity
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Long-term Neuronal Synaptic Plasticity
Cell Death
Programmed Cell Death
Response To Radiation
Cellular Response To Gamma Radiation
Glucose Catabolic Process
Signal Transduction
Response To Ethanol
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Inclusion Body
Cytoplasm
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Amyloid-beta Formation
Regulation Of Amide Metabolic Process
Molecular Adaptor Activity
Regulation Of Cell Cycle G1/S Phase Transition
Nucleus
Chromatin Binding
Cytosol
Protein Sequestering Activity
Regulation Of Chaperone-mediated Autophagy
Regulation Of Amyloid-beta Formation
Negative Regulation Of Growth
Cuprous Ion Binding
Regulation Of Protein Catabolic Process
Regulation Of Amyloid Precursor Protein Catabolic Process
Response To Phorbol 13-acetate 12-myristate
Regulation Of Cell Population Proliferation
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Regulation Of Interleukin-2 Production
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of SMAD Protein Signal Transduction
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Cell Growth
Identical Protein Binding
Regulation Of Cell Development
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Activation
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Projection Organization
Cell Cycle G1/S Phase Transition
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Tagcloud (Difference)
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Tagcloud (Intersection)
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