RAP1B and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RAP1B	DDAH2
Description		RAP1B, member of RAS oncogene family	DDAH family member 2, ADMA-independent
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Cytoplasm Mitochondrion Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Protein Binding Dimethylargininase Activity Hydrolase Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Citrulline Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Citrulline
Diseases
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	28 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SCGN SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		5908	23564
HPRD ID		01546	09204
Ensembl ID		ENSG00000127314	ENSG00000213722
Uniprot IDs		B7ZAY2 P61224	O95865 V9HW53
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication	Cytoplasm Nucleus Regulation Of Mitotic Cell Cycle Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Cytosol Regulation Of Cell Cycle Process Protein Kinase Activity JNK Cascade Response To Phorbol 13-acetate 12-myristate Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Epithelial Cell Proliferation Cellular Response To UV-B Protein Phosphorylation Identical Protein Binding Intracellular Signaling Cassette Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Phosphorylation Magnesium Ion Binding Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Phase Transition Regulation Of Translation In Response To Stress Positive Regulation Of JNK Cascade Response To UV-B Regulation Of Cell Cycle Phase Transition Cellular Response To Gamma Radiation Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process Protein Binding Z Disc Phosphate-containing Compound Metabolic Process Signal Transduction Nucleotide Binding ATP Binding Cyclin Binding Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Nuclear Division Cis-trans Isomerase Activity Positive Regulation Of Apoptotic Process Histone H2AS1 Kinase Activity Positive Regulation Of Mitotic DNA Damage Checkpoint
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