APLP1 and HLA-DQA1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APLP1	HLA-DQA1
Gene Name		amyloid beta (A4) precursor-like protein 1	major histocompatibility complex, class II, DQ alpha 1
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	MRNA Polyadenylation Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nervous System Development Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of CAMP Biosynthetic Process Forebrain Development Cellular Response To Norepinephrine Stimulus	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of T Cell Differentiation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Asthma ( 23181788) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656) Chronic lymphocytic leukemia ( 21131588) Crohn's disease ( 23266558) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) Immune response to anthrax vaccine ( 22658931) Inflammatory bowel disease ( 18758464) Leishmaniasis (visceral) ( 23291585) Lymphoma ( 23349640) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nephropathy (idiopathic membranous) ( 21323541) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 21653640) Schizophrenia ( 23212062 19571809) Systemic lupus erythematosus ( 18204098 21408207) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 21297633 19122664 23511034) Vitiligo ( 20410501)
Protein-Protein Interactions		43 interactors: ANXA7 APBB1 APBB3 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	8 interactors: APLP1 CD74 CDK7 IKBKG LRIF1 SH3GL2 TLE1 UNC119
Entrez ID		333	3117
HPRD ID		00102	06765
Ensembl ID		ENSG00000105290	ENSG00000196735
Uniprot IDs		F5GZ08 P51693	B7ZW51 L8E864 P01909 Q08AS3 Q30063 Q5Y7H0 Q8MH44
PDB IDs		3PMR 3Q7G 3Q7L 3QMK	1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Anatomical Structure Development Positive Regulation Of Protein Metabolic Process System Development Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Regulation Of Phosphorylation Response To Organic Substance Regulation Of Gene Expression Response To Copper Ion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Process Regulation Of Cell Proliferation Positive Regulation Of Protein Phosphorylation Cellular Aromatic Compound Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Death Regulation Of Kinase Activity Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Growth Response To Growth Factor Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Response To Organic Cyclic Compound Digestive Tract Development Negative Regulation Of Cellular Metabolic Process Cell Cycle Arrest RNA Metabolic Process Response To Inorganic Substance Regulation Of Cell Cycle Digestive System Development Negative Regulation Of Cell Growth G1/S Transition Of Mitotic Cell Cycle	Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Signaling Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Clathrin-mediated Endocytosis Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Signaling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Protein Kinase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Kinase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transferase Activity Negative Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stimulus Activation Of MAPK Activity Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis RNA Metabolic Process Response To Norepinephrine Intracellular Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Localization Positive Regulation Of MAP Kinase Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Gene Expression Mitotic Cytokinetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
Tagcloud (Difference) ?		abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
Tagcloud (Intersection) ?