RAP1B

Gene Name		RAP1B, member of RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS		White blood cell count ( 20139978)
Protein-protein Interactions		29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		5908
HPRD ID		01546
Ensembl ID		ENSG00000127314
Uniprot IDs		B7ZAY2 P61224
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus