APLP1 and HSPE1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		APLP1	HSPE1
Name		amyloid beta precursor like protein 1	heat shock protein family E (Hsp10) member 1
Structure
GO Annotations	Cellular Component	Basement Membrane Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Axonogenesis Central Nervous System Development Animal Organ Morphogenesis Extracellular Matrix Organization Forebrain Development Animal Organ Development Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosolic MRNA Polyadenylation	Osteoblast Differentiation Protein Folding Response To Unfolded Protein Intrinsic Apoptotic Signaling Pathway
Pathways		None	RHOG GTPase cycle Mitochondrial unfolded protein response (UPRmt)
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Phenethyl Isothiocyanate
GWAS		Severe influenza A (H1N1) infection ( 26379185 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Schizophrenia ( 25056061 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		42 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	17 interacting genes: ALDH2 APLP1 CASP3 CRMP1 EEF1A1 ERG28 GBP2 HSPD1 LINC00632 LRIF1 NTAQ1 SAT1 SELENOM STK3 TLE1 UNC119 ZHX1
Entrez ID		333	3336
HPRD ID		00102	02535
Ensembl ID		ENSG00000105290	ENSG00000115541
Uniprot IDs		P51693	A0A384N6A4 P61604
PDB IDs		3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA	4PJ1 6HT7 6MRC 6MRD 8G7N 8G7O
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Inclusion Body Cytoplasm Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Molecular Adaptor Activity Regulation Of Cell Cycle G1/S Phase Transition Nucleus Chromatin Binding Cytosol Protein Sequestering Activity Regulation Of Chaperone-mediated Autophagy Regulation Of Amyloid-beta Formation Negative Regulation Of Growth Cuprous Ion Binding Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Response To Phorbol 13-acetate 12-myristate Regulation Of Cell Population Proliferation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Regulation Of Interleukin-2 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of SMAD Protein Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Growth Identical Protein Binding Regulation Of Cell Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Activation G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Projection Organization Cell Cycle G1/S Phase Transition	Positive Regulation Of Pyroptotic Inflammatory Response