RAP1B and ZNF135

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RAP1B	ZNF135
Gene Name		RAP1B, member of RAS oncogene family	zinc finger protein 135
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome	Nucleus
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Morphogenesis
Pathways		Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System	Generic Transcription Pathway
Drugs
Diseases
GWAS		White blood cell count ( 20139978)
Protein-Protein Interactions		29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	6 interactors: ANXA7 CDKN1A GADD45A GSK3B RAP1B RCC1
Entrez ID		5908	7694
HPRD ID		01546	07242
Ensembl ID		ENSG00000127314	ENSG00000176293
Uniprot IDs		B7ZAY2 P61224	B4DLZ7 P52742 Q8N9M3
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization	Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Regulation Of Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Metabolic Process Cellular Response To Heat Positive Regulation Of Ras GTPase Activity Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Ras GTPase Activity Epithelial Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Response To Heat Positive Regulation Of Cell Death Response To Stress Tissue Development Regulation Of Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction
Tagcloud ?		adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?