RAP1B and RAB7B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAP1B	RAB7B
Gene Name		RAP1B, member of RAS oncogene family	RAB7B, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome	Lysosome Late Endosome Golgi Apparatus Trans-Golgi Network Phagocytic Vesicle Membrane Phagocytic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding	GTP Binding
	Biological Process	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Late Endosome To Golgi Transport Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS		White blood cell count ( 20139978)
Protein-Protein Interactions		29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	2 interactors: APP RAP1B
Entrez ID		5908	338382
HPRD ID		01546	15202
Ensembl ID		ENSG00000127314
Uniprot IDs		B7ZAY2 P61224	Q96AH8
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization	Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Negative Regulation Of Synaptic Vesicle Exocytosis Blood Coagulation Hemostasis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Neuron Differentiation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Neuron Remodeling Rap Protein Signal Transduction Cell Activation Response To Wounding Regulation Of Neurogenesis Negative Regulation Of Neurotransmitter Transport Regulation Of Protein Kinase Activity Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Kinase Activity Regulation Of Cell Development Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Cellular Copper Ion Homeostasis Regulation Of Synaptic Vesicle Exocytosis Regulation Of Rap GTPase Activity Copper Ion Homeostasis Suckling Behavior Positive Regulation Of Hydrolase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Negative Regulation Of Exocytosis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Endothelial Barrier Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Synaptic Vesicle Transport Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorylation RNA Polyadenylation
Tagcloud ?		adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus	carrier carriers cation collectively compartments endosome endosomes golgi gtpase impairs indeed localizes lysosomes mannose missorting mpr mprs phosphate q67l retrieval sorted sortilin sorting special tgn trafficking transport tubular tubulation
Tagcloud (Difference) ?		adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular complement dense discovered discoveries fibrinogen granule integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus	carrier carriers cation compartments endosome endosomes golgi impairs indeed localizes lysosomes mannose missorting mpr mprs phosphate q67l retrieval sorted sortilin sorting special tgn trafficking transport tubular tubulation
Tagcloud (Intersection) ?		collectively gtpase