RAP1B and RAB7B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAP1B	RAB7B
Description		RAP1B, member of RAS oncogene family	RAB7B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Lysosome Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Late Endosome Membrane Phagocytic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Immune System Process Endosome To Lysosome Transport Protein Transport Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Late Endosome To Golgi Transport Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Type II Interferon Phagosome-lysosome Fusion
Pathways		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants	TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)
Interacting Genes		31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	3 interacting genes: APP APPBP2 RAP1B
Entrez ID		5908	338382
HPRD ID		01546	15202
Ensembl ID		ENSG00000127314	ENSG00000276600
Uniprot IDs		B7ZAY2 P61224	A0A096LP44 Q96AH8
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Response To CAMP Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Junction Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Establishment Of Localization In Cell Synapse Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Calcium Ion-dependent Exocytosis Rap Protein Signal Transduction Antifungal Humoral Response Nuclear Envelope Lumen
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