APLP1 and PCDHA4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APLP1	PCDHA4
Description		amyloid beta precursor like protein 1	protocadherin alpha 4
Image			No pdb structure
GO Annotations	Cellular Component	Basement Membrane Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Axonogenesis Central Nervous System Development Animal Organ Morphogenesis Extracellular Matrix Organization Forebrain Development Animal Organ Development Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosolic MRNA Polyadenylation	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development
Pathways
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Severe influenza A (H1N1) infection ( 26379185)	Neutrophil count ( 27863252) Schizophrenia ( 28991256 29483656) Sum basophil neutrophil counts ( 27863252)
Interacting Genes		42 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	16 interacting genes: APLP1 CCDC90B EEF1A1 ERG28 GAPDH GDF9 IGSF21 LRIF1 RBM48 RELN SETDB1 SGTA TLE1 TP53 UBQLN1 UNC119
Entrez ID		333	56144
HPRD ID		00102	07322
Ensembl ID		ENSG00000105290	ENSG00000204967
Uniprot IDs		P51693	Q59H34 Q9UN74
PDB IDs		3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Inclusion Body Cytoplasm Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Molecular Adaptor Activity Regulation Of Cell Cycle G1/S Phase Transition Nucleus Chromatin Binding Cytosol Protein Sequestering Activity Regulation Of Chaperone-mediated Autophagy Regulation Of Amyloid-beta Formation Negative Regulation Of Growth Cuprous Ion Binding Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Response To Phorbol 13-acetate 12-myristate Regulation Of Cell Population Proliferation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Regulation Of Interleukin-2 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of SMAD Protein Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Growth Identical Protein Binding Regulation Of Cell Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Activation G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Projection Organization Cell Cycle G1/S Phase Transition
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