RAP1B and CSAD

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RAP1B	CSAD
Description		RAP1B, member of RAS oncogene family	cysteine sulfinic acid decarboxylase
Image
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Aspartate 1-decarboxylase Activity Sulfinoalanine Decarboxylase Activity Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	L-cysteine Catabolic Process To Hypotaurine L-cysteine Catabolic Process To Taurine Carboxylic Acid Metabolic Process Taurine Biosynthetic Process
Pathways		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Degradation of cysteine and homocysteine
Drugs			Pyridoxal phosphate Cysteine
Diseases
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)	Fulminant type 1 diabetes ( 30552108) Obesity-related traits ( 23251661)
Interacting Genes		31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	11 interacting genes: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SH2B1 SMN1 TK1
Entrez ID		5908	51380
HPRD ID		01546	16763
Ensembl ID		ENSG00000127314	ENSG00000139631
Uniprot IDs		B7ZAY2 P61224	Q86V02 Q96JQ3 Q9Y600
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V	2JIS
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication	Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Exocytosis Vesicle Membrane Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Tau Protein Binding Calcium-dependent Phospholipid Binding Regulation Of Organelle Organization Phosphatidylserine Binding Small GTPase-mediated Signal Transduction Regulation Of Microtubule Anchoring At Centrosome Cis-trans Isomerase Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Cellular Developmental Process Keratinocyte Differentiation Cytosol Regulation Of SMAD Protein Signal Transduction Calcium-dependent Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Thymidine Kinase Activity Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of DNA Biosynthetic Process Epithelial Cell Differentiation Cell Differentiation Epidermal Cell Differentiation Positive Regulation Of Protein Modification Process Intracellular Signaling Cassette Cellular Component Assembly Beta-catenin Binding Protein Peptidyl-prolyl Isomerization
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