RAP1B and RAPGEF1

Number of citations: 69 (PubMedID 8524240)
Data Source: HPRD (in vitro, in vivo)

		RAP1B	RAPGEF1
Name		RAP1B, member of RAS oncogene family	Rap guanine nucleotide exchange factor 1
Structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
GWAS		Femoral neck bone mineral density ( 32239398 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) HDL cholesterol levels in HIV infection ( 33109212 ) White blood cell count ( 20139978 )	Cerebrospinal fluid α-synuclein levels ( 29959729 ) Cutaneous malignant melanoma ( 32341527 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Kidney volume ( 34128465 ) Nevus count or cutaneous melanoma ( 32341527 ) Optic disc size ( 31809533 )
Interacting Genes		31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		5908	2889
HPRD ID		01546	02627
Ensembl ID		ENSG00000127314	ENSG00000107263
Uniprot IDs		B7ZAY2 P61224	A0A1S5UYZ7 A0A804HL87 Q13905
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V	5L23
GO Terms Enriched among Interactors		Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Small GTPase-mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament-based Process Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway GDP Binding Regulation Of Protein Localization To Membrane Regulation Of Cell Migration Response To Growth Factor Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Locomotion Positive Regulation Of Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Rap Protein Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Focal Adhesion Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Lymphocyte Migration Cytosol Cell Motility GTPase Activity