RAP1B and RGL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		RAP1B	RGL2
Description		RAP1B, member of RAS oncogene family	ral guanine nucleotide dissociation stimulator like 2
Image
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Cell Population Proliferation Calcium-ion Regulated Exocytosis Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Localization In Cell Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Modification Of Postsynaptic Structure Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Ral Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants	RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		31 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 DVL2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135	19 interacting genes: ADAMTSL4 CCDC90B CRMP1 CYSRT1 EEF1G GORASP2 HRAS KAT5 KAT7 KPNA2 KPRP KRAS KRTAP10-8 NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119
Entrez ID		5908	5863
HPRD ID		01546	03810
Ensembl ID		ENSG00000127314	ENSG00000237441
Uniprot IDs		B7ZAY2 P61224	A0A024RCS9 O15211
PDB IDs		3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK 7C7I 7C7J 8SU8 8T09 8T7V	8AU4 8B69
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Regulation Of Carbohydrate Catabolic Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Regulation Of Purine Nucleotide Metabolic Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Small GTPase-mediated Signal Transduction Regulation Of NADP Metabolic Process Regulation Of JNK Cascade Regulation Of Primary Metabolic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Lipoprotein Transport Cellular Response To Catecholamine Stimulus Response To CAMP Transition Metal Ion Binding Response To Catecholamine Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Glycolytic Process Regulation Of Translation Positive Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Cell Death Programmed Cell Death Response To Radiation Cellular Response To Gamma Radiation Glucose Catabolic Process Signal Transduction Response To Ethanol Regulation Of Cell Communication	G Protein Activity GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Ras Protein Signal Transduction Intracellular Signaling Cassette Regulation Of Neuronal Synaptic Plasticity Histone H4K16 Acetyltransferase Activity Intracellular Signal Transduction Histone H4 Acetyltransferase Activity Developmental Process Peptidyl-lysine Acetylation Positive Regulation Of Ruffle Assembly Cell Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rac Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Golgi Membrane Regulation Of Ruffle Assembly Protein-containing Complex Binding Negative Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Activity Protein Acetylation Protein-membrane Adaptor Activity Endoplasmic Reticulum Membrane Establishment Of Skin Barrier Homeostasis Of Number Of Cells Within A Tissue Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly Histone H2AK5 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Pigment Cell Development Skin Epidermis Development Hydrolase Activity Response To Radiation Endocytosis Regulation Of Cell Projection Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Cellular Developmental Process GTPase Complex Cellular Senescence Modulation Of Chemical Synaptic Transmission MAPK Cascade Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?