MSH2 and RPP14

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MSH2	RPP14
Gene Name		mutS homolog 2	ribonuclease P/MRP 14kDa subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleoplasm Membrane MutSalpha Complex MutSbeta Complex	Nucleus
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding	RNA Binding Ribonuclease P Activity
	Biological Process	Meiotic Mismatch Repair In Utero Embryonic Development Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Meiotic Gene Conversion Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Negative Regulation Of Reciprocal Meiotic Recombination Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	TRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP ESR1 ESR2 EXO1 GRB7 HUS1 MAX MSH3 MSH6 PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 TK1 TREX1 XPA	19 interactors: A2M ATP5B CAPZB DOCK7 EXOSC8 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ
Entrez ID		4436	11102
HPRD ID		00389	18001
Ensembl ID		ENSG00000095002	ENSG00000163684
Uniprot IDs		E9PHA6 P43246	O95059
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Damage Checkpoint Cell Cycle Process Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Ionizing Radiation Response To Abiotic Stimulus DNA Replication Negative Regulation Of DNA Metabolic Process Response To Stimulus Mismatch Repair Cellular Response To Ionizing Radiation Cellular Response To Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Catabolic Process, Exonucleolytic Negative Regulation Of DNA Replication Regulation Of DNA Replication Response To UV Developmental Process DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Checkpoint Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Meiotic Cell Cycle Cellular Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Meiotic Mismatch Repair Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins	RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis TRNA Processing TRNA Metabolic Process NcRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Reciprocal Meiotic Recombination Negative Regulation Of Complement Activation, Lectin Pathway Ribonucleoprotein Complex Biogenesis Meiotic Mismatch Repair Establishment Of Neuroblast Polarity Mitotic DNA Damage Checkpoint Cellular Metabolic Process Mitotic DNA Integrity Checkpoint Gene Silencing Meiotic Gene Conversion Maintenance Of DNA Repeat Elements Positive Regulation Of Gene Silencing By MiRNA Generation Of Precursor Metabolites And Energy Signal Transduction By P53 Class Mediator Positive Regulation Of Nuclear Cell Cycle DNA Replication
Tagcloud ?		adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Difference) ?		adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Intersection) ?