MSH2 and MSH3

Number of citations of the paper that reports this interaction (PubMedID 9774676)
37

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MSH2	MSH3
Description		mutS homolog 2	mutS homolog 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MutSalpha Complex MutSbeta Complex	Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Mitotic Recombination DNA Damage Response Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Mitotic Intra-S DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Cycle	DNA Repair Mismatch Repair Mitotic Recombination DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer	Colorectal cancer
GWAS		Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		51 interacting genes: AKT1 ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CEBPA CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 FILNC1 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MLH1 MSH3 MSH6 OTUB1 PCNA PDE4B PPP3R2 RAD1 RAD9A RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510	14 interacting genes: BARD1 BRCA1 ERG EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 SUMO2 TSC22D2 XPA
Entrez ID		4436	4437
HPRD ID		00389	02931
Ensembl ID		ENSG00000095002	ENSG00000113318
Uniprot IDs		A0A2R8Y6P0 A0A2R8YFH0 A0A2R8YG02 A0AAQ5BH31 E9PHA6 P43246	P20585
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ 8AG6 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9	3THW 3THX 3THY 3THZ 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Cellular Response To Ionizing Radiation Response To Radiation Cellular Response To Stress Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mismatch Repair Response To UV Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Response To Stress Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Intrinsic Apoptotic Signaling Pathway MutLalpha Complex Binding Nucleoplasm Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Mitotic Cell Cycle Cellular Response To Gamma Radiation Regulation Of DNA Metabolic Process Signal Transduction Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Guanine/thymine Mispair Binding Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Somatic Cell DNA Recombination Checkpoint Clamp Complex Regulation Of Mitotic Cell Cycle Cellular Response To UV Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Stress Damaged DNA Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Checkpoint Clamp Complex Mismatch Repair DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Postreplication Repair DNA Recombination Negative Regulation Of Cell Cycle Process Nucleoplasm Response To Stress Signal Transduction In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes DNA Strand Resection Involved In Replication Fork Processing Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Dinucleotide Insertion Or Deletion Binding Somatic Recombination Of Immunoglobulin Gene Segments BRCA1-B Complex Homologous Recombination Guanine/thymine Mispair Binding Apoptotic Signaling Pathway Somatic Diversification Of Immunoglobulins Chromosome Organization Response To UV Somatic Cell DNA Recombination Regulation Of Cell Cycle
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