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MSH2 and RAD9A
Number of citations of the paper that reports this interaction (PubMedID
20188637
)
89
Data Source:
BioGRID
(far western blotting)
MSH2
RAD9A
Description
mutS homolog 2
RAD9 checkpoint clamp component A
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Membrane
MutSalpha Complex
MutSbeta Complex
Nucleus
Nucleoplasm
Cytoplasm
Checkpoint Clamp Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
ATP Hydrolysis Activity
Centromeric DNA Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
ATP-dependent DNA Damage Sensor Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Hydrolase Activity
SH3 Domain Binding
Enzyme Binding
Protein Kinase Binding
Histone Deacetylase Binding
Biological Process
In Utero Embryonic Development
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
Oxidative Phosphorylation
DNA Repair
Mismatch Repair
Postreplication Repair
Double-strand Break Repair
Mitotic Recombination
DNA Damage Response
Germ Cell Development
Determination Of Adult Lifespan
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To X-ray
Response To UV-B
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
B Cell Mediated Immunity
B Cell Differentiation
Mitotic Intra-S DNA Damage Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Cell Cycle
DNA Replication Checkpoint Signaling
DNA Damage Checkpoint Signaling
DNA Repair
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mitotic Intra-S DNA Damage Checkpoint Signaling
Cellular Response To Ionizing Radiation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
TP53 Regulates Transcription of DNA Repair Genes
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Diseases
Ovarian cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
GWAS
Electroencephalogram traits (
25387704
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Interacting Genes
51 interacting genes:
AKT1
ANXA7
APPBP2
ATR
BARD1
BRCA1
CCDC180
CDC14B
CDC42
CDKN1A
CEBPA
CHEK2
CREBBP
DVL1
EPHA2
ESR1
ESR2
EXO1
FBP1
FBP2
FGFR4
FILNC1
GALNT12
GRB7
HDAC6
HRAS
HUS1
LEF1
MAX
MLH1
MSH3
MSH6
OTUB1
PCNA
PDE4B
PPP3R2
RAD1
RAD9A
RPP14
SMAD1
SMC1A
SMN1
STX17
SUMO2
TDRD7
TK1
TREX1
TRIM29
USP10
XPA
ZNF510
39 interacting genes:
ABL1
AR
ATAD5
ATM
BCL2
BCL2L1
CAD
CDK1
CHEK2
CLSPN
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEM1B
FEN1
HDAC1
HUS1
HUS1B
ITSN2
MLH1
MSH2
MSH3
MSH6
NR3C1
OGG1
PCNA
POLB
PRKCE
RAD17
RAD9B
RHNO1
RPA1
RPA2
SF3B3
TDG
TLK1
TOPBP1
WRN
Entrez ID
4436
5883
HPRD ID
00389
04788
Ensembl ID
ENSG00000095002
ENSG00000172613
Uniprot IDs
A0A2R8Y6P0
A0A2R8YFH0
A0A2R8YG02
A0AAQ5BH31
E9PHA6
P43246
Q99638
PDB IDs
2O8B
2O8C
2O8D
2O8E
2O8F
3THW
3THX
3THY
3THZ
8AG6
8OLX
8OM5
8OM9
8OMA
8OMO
8OMQ
8R7C
8R7E
8R7V
8RZ7
8RZ8
8RZ9
3A1J
3G65
3GGR
6HM5
6J8Y
7Z6H
8GNN
8JZY
8WU8
Enriched GO Terms of Interacting Partners
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DNA Repair
DNA Metabolic Process
DNA Damage Response
Cellular Response To Radiation
Cellular Response To Ionizing Radiation
Response To Radiation
Cellular Response To Stress
Intracellular Signal Transduction
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Response To Ionizing Radiation
DNA Damage Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mismatch Repair
Response To UV
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
Response To Stress
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Intrinsic Apoptotic Signaling Pathway
MutLalpha Complex Binding
Nucleoplasm
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Mitotic Cell Cycle
Cellular Response To Gamma Radiation
Regulation Of DNA Metabolic Process
Signal Transduction
Enzyme Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Damaged DNA Binding
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Guanine/thymine Mispair Binding
Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Somatic Cell DNA Recombination
Checkpoint Clamp Complex
Regulation Of Mitotic Cell Cycle
Cellular Response To UV
Regulation Of Cell Cycle
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
DNA Recombination
Double-strand Break Repair
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Mismatch Repair
Response To Stress
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Chromosome Organization
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Macromolecule Metabolic Process
Nucleoplasm
Intracellular Signal Transduction
Response To Ionizing Radiation
Response To Radiation
Damaged DNA Binding
Nucleus
Regulation Of DNA Metabolic Process
Protein Localization To Site Of Double-strand Break
Recombinational Repair
Mitotic Intra-S DNA Damage Checkpoint Signaling
Base-excision Repair
Enzyme Binding
Regulation Of Mitotic Cell Cycle
DNA Replication Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Response To Stress
Chromosome, Telomeric Region
Somatic Cell DNA Recombination
Mitotic DNA Replication Checkpoint Signaling
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of DNA Recombination
Mismatched DNA Binding
Regulation Of DNA Recombination
Guanine/thymine Mispair Binding
Mitotic G2/M Transition Checkpoint
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Tagcloud (Intersection)
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