MSH2 and MSH6

Number of citations of the paper that reports this interaction (PubMedID 31839598)
57

Data Source:
BioGRID (cross-linking study)
HPRD (in vivo, in vitro, two hybrid)

		MSH2	MSH6
Description		mutS homolog 2	mutS homolog 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MutSalpha Complex MutSbeta Complex	Chromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol MutSalpha Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding Histone H3K36me3 Reader Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Mitotic Recombination DNA Damage Response Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Mitotic Intra-S DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Cycle	Meiotic Mismatch Repair DNA Repair Mismatch Repair Chromatin Organization DNA Damage Response Spermatogenesis Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6
Drugs
Diseases		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer
GWAS		Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)	General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Menopause (age at onset) ( 26414677) Takayasu arteritis ( 25604533) Tea consumption ( 31046077)
Interacting Genes		51 interacting genes: AKT1 ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CEBPA CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 FILNC1 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MLH1 MSH3 MSH6 OTUB1 PCNA PDE4B PPP3R2 RAD1 RAD9A RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510	20 interacting genes: BARD1 BRCA1 CEBPA CHAF1A CREBBP CSNK2A1 EP300 HRAS HUS1 MAP2K1 MSH2 MUTYH NANS PCNA PTEN RAD1 RAD9A SMC1A SUMO2 WEE2-AS1
Entrez ID		4436	2956
HPRD ID		00389	07202
Ensembl ID		ENSG00000095002	ENSG00000116062
Uniprot IDs		A0A2R8Y6P0 A0A2R8YFH0 A0A2R8YG02 A0AAQ5BH31 E9PHA6 P43246	A0A494C0M1 A0A8V8TPJ4 P52701 Q3SWU9
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ 8AG6 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F 6OQM 8AG6
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Cellular Response To Ionizing Radiation Response To Radiation Cellular Response To Stress Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mismatch Repair Response To UV Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Response To Stress Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Intrinsic Apoptotic Signaling Pathway MutLalpha Complex Binding Nucleoplasm Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Mitotic Cell Cycle Cellular Response To Gamma Radiation Regulation Of DNA Metabolic Process Signal Transduction Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Guanine/thymine Mispair Binding Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Somatic Cell DNA Recombination Checkpoint Clamp Complex Regulation Of Mitotic Cell Cycle Cellular Response To UV Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process	Cellular Response To Radiation DNA Repair DNA Damage Response Response To Radiation DNA Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Response To Stress Nucleic Acid Metabolic Process Regulation Of Cell Cycle Checkpoint Clamp Complex Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition MutLalpha Complex Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Cell Cycle Process Regulation Of Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Nucleus DNA Recombination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Transcription By RNA Polymerase II BRCA1-BARD1 Complex Chromatin Binding Response To UV Histone H3K27 Acetyltransferase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Catabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process
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