MSH2 and ANXA7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MSH2	ANXA7
Description		mutS homolog 2	annexin A7
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MutSalpha Complex MutSbeta Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Chromaffin Granule Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding ATP-dependent DNA Damage Sensor Activity	Phosphatidylserine Binding RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Mitotic Recombination DNA Damage Response Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Mitotic Intra-S DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Cycle	Autophagy Negative Regulation Of Gene Expression Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion Response To Phorbol 13-acetate 12-myristate
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer
GWAS		Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)	Copper levels ( 26025379)
Interacting Genes		51 interacting genes: AKT1 ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CEBPA CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 FILNC1 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MLH1 MSH3 MSH6 OTUB1 PCNA PDE4B PPP3R2 RAD1 RAD9A RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510	109 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CREBBP CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 HUNK INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OGT OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		4436	310
HPRD ID		00389	01720
Ensembl ID		ENSG00000095002	ENSG00000138279
Uniprot IDs		A0A2R8Y6P0 A0A2R8YFH0 A0A2R8YG02 A0AAQ5BH31 E9PHA6 P43246	B2R657 P20073
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ 8AG6 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9	8W5S
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Cellular Response To Ionizing Radiation Response To Radiation Cellular Response To Stress Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mismatch Repair Response To UV Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Response To Stress Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Intrinsic Apoptotic Signaling Pathway MutLalpha Complex Binding Nucleoplasm Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Mitotic Cell Cycle Cellular Response To Gamma Radiation Regulation Of DNA Metabolic Process Signal Transduction Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Guanine/thymine Mispair Binding Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Somatic Cell DNA Recombination Checkpoint Clamp Complex Regulation Of Mitotic Cell Cycle Cellular Response To UV Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process	TORC1 Signaling Extracellular Exosome TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Metabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Cytoplasm Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Extracellular Matrix Positive Regulation Of Biosynthetic Process Positive Regulation Of TOR Signaling Developmental Process Regulation Of Metabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Protein Deubiquitination Cellular Response To Nutrient Levels Regulation Of Proteolysis Histone H3T6 Kinase Activity Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Metabolic Process Platelet Alpha Granule Lumen Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Blood Microparticle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Cytoplasmic Translation Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Matrix Response To Interleukin-1 Response To Cytokine Regulation Of Protein Localization Negative Regulation Of Signal Transduction Calyx Of Held Negative Regulation Of Translational Initiation Protein Kinase C Signaling Proteasomal Protein Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?