IGFBP6 and DDX10

		IGFBP6	DDX10
Description		insulin like growth factor binding protein 6	DEAD-box helicase 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	RRNA Processing Anterior Head Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)
Interacting Genes		38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	4 interacting genes: APP FBXO7 RNF10 SIRPA
Entrez ID		3489	1662
HPRD ID		00902	03138
Ensembl ID		ENSG00000167779	ENSG00000178105
Uniprot IDs		F8VVA5 P24592	Q13206
PDB IDs		1RMJ 2JM2	2PL3
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location
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