IGFBP6 and TF

Number of citations of the paper that reports this interaction (PMID 11297622)
20

Data Source:
HPRD (in vitro)

		IGFBP6	TF
Gene Name		insulin-like growth factor binding protein 6	transferrin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation
Drugs			Aluminium
Diseases
GWAS			Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)
Protein-Protein Interactions		4 interactors: IGF1 IGF2 TF UBQLN4	20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1
Entrez ID		3489	7018
HPRD ID		00902	01811
Ensembl ID		ENSG00000167779	ENSG00000091513
Uniprot IDs		P24592	A0PJA6 J3KN47 P02787 Q06AH7
PDB IDs		1RMJ	1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Exocytosis Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Body Fluid Levels Positive Regulation Of Protein Kinase B Signaling Wound Healing Positive Regulation Of T Cell Proliferation Secretion Cell Activation Pancreas Development Response To Wounding Regulation Of Glucose Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Glycogen (starch) Synthase Activity Ossification Positive Regulation Of Cell Cycle	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation
Tagcloud ?		1ra afgf basement c5a cyr61 endocan endoglin endostatin engelbreth fetuin gelled holm interpretations lipocalin matrigel mig osteopontin pentraxin plgf rbp4 resistin serpin sicam swarm timp xviii	alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf
Tagcloud (Difference) ?		1ra afgf basement c5a cyr61 endocan endoglin endostatin engelbreth fetuin gelled holm interpretations lipocalin matrigel mig osteopontin pentraxin plgf rbp4 resistin serpin sicam swarm timp xviii	alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf
Tagcloud (Intersection) ?