IGFBP6 and ALPP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGFBP6	ALPP
Description		insulin like growth factor binding protein 6	alkaline phosphatase, placental
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex	Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Intra-Golgi traffic
Drugs			Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	47 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1
Entrez ID		3489	250
HPRD ID		00902	01379
Ensembl ID		ENSG00000167779	ENSG00000163283
Uniprot IDs		F8VVA5 P24592	B2R7C7 P05187
PDB IDs		1RMJ 2JM2	1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding
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