IGFBP6 and EPDR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGFBP6	EPDR1
Description		insulin like growth factor binding protein 6	ependymin related 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex	Extracellular Region Lysosome Lysosomal Lumen
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Phospholipid Binding Lipid Binding Identical Protein Binding Ganglioside GM1 Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Cell-matrix Adhesion Myofibroblast Contraction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Dupuytren's disease ( 21732829 28886342) Glaucoma (primary angle closure) ( 27064256) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lateral ventricle volume ( 31530798) Lumbar spine bone mineral density ( 29499414) Rosacea symptom severity ( 29771307)
Interacting Genes		38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	13 interacting genes: ADAMTSL4 EHMT2 HOXA1 IGFBP6 KRT31 KRT34 KRTAP10-8 KRTAP13-2 KRTAP4-11 PM20D2 TNS2 TRIP6 UBQLN4
Entrez ID		3489	54749
HPRD ID		00902	16865
Ensembl ID		ENSG00000167779	ENSG00000086289
Uniprot IDs		F8VVA5 P24592	Q96J80 Q9UM22
PDB IDs		1RMJ 2JM2	6E7O 6E8N 6JLD
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance	Keratin Filament Intermediate Filament Identical Protein Binding Structural Molecule Activity Negative Regulation Of Macroautophagy Semicircular Canal Formation Insulin-like Growth Factor Binary Complex Histone H3K56 Methyltransferase Activity Pigment Cell Development Para-aminobenzoyl-glutamate Hydrolase Activity Structural Constituent Of Skin Epidermis Abducens Nerve Formation Optokinetic Behavior Intermediate Filament Organization Nuclear Proteasome Complex Folic Acid Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Phenotypic Switching Negative Regulation Of Autophagosome Maturation Kinase Binding Negative Regulation Of Autophagy
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