IGFBP6 and RANBP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGFBP6	RANBP10
Description		insulin like growth factor binding protein 6	RAN binding protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Beta-tubulin Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Microtubule Cytoskeleton Organization Cytoskeleton Organization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	MET activates RAS signaling
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Empathy quotient ( 29527006) HDL cholesterol ( 25961943) Hematocrit ( 27863252 32888494) Hemoglobin concentration ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	15 interacting genes: CACHD1 CNTNAP4 CTAG1A CTAG1B IGFBP6 IGSF1 MAGEA11 MEGF10 MET NEDD4 NEDD4L PRKCG RAN THSD7B TSEN2
Entrez ID		3489	57610
HPRD ID		00902	15207
Ensembl ID		ENSG00000167779	ENSG00000141084
Uniprot IDs		F8VVA5 P24592	B3KP49 Q6VN20 R4GMX8
PDB IDs		1RMJ 2JM2
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance	Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport TRNA Threonylcarbamoyladenosine Metabolic Process Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development TRNA Metabolic Process Insulin-like Growth Factor Binary Complex Hepatocyte Growth Factor Receptor Activity Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Activin Receptor Antagonist Activity Receptor Internalization Regulation Of Dendrite Morphogenesis Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Sodium Ion Transport Protein Monoubiquitination RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus TRNA-intron Lyase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?