APOA5 and FAS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		APOA5	FAS
Gene Name		apolipoprotein A-V	Fas cell surface death receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Blood Microparticle	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Phospholipid Binding Enzyme Activator Activity Heparin Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Lipid Transport Response To Hormone Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Neuron Projection Regeneration Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Lipoprotein Lipase Activity Acylglycerol Homeostasis Triglyceride Homeostasis	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport	Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990 21347282) HDL cholesterol ( 20864672 19060906 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 21386085) Metabolite levels ( 22916037) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Response to Vitamin E supplementation ( 22437554) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 22171074 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)	Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: FAS RAB5B SMARCD1	48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1
Entrez ID		116519	355
HPRD ID		06966	00609
Ensembl ID		ENSG00000110243	ENSG00000026103
Uniprot IDs		Q6Q788	P25445
PDB IDs			1BZI 1DDF 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Motor Neuron Apoptotic Process Necroptotic Signaling Pathway Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Plasma Membrane To Endosome Transport Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Chromatin-mediated Maintenance Of Transcription Pantothenate Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Nucleosome Disassembly Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Response To Lithium Ion T Cell Apoptotic Process Positive Regulation Of Gene Expression, Epigenetic Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Regulation Of Protein Oligomerization Endosome Organization Response To Lithium Ion Necroptotic Process Response To Hyperoxia Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T Cell Selection Cellular Response To Interleukin-4 Spleen Development Triglyceride Biosynthetic Process Programmed Necrotic Cell Death Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Interleukin-4 Neuron Apoptotic Process Rab Protein Signal Transduction Immunoglobulin Production Acyl-CoA Metabolic Process Neuron Death T Cell Differentiation In Thymus Lymphocyte Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response
Tagcloud ?		ago alleles apolipoprotein carriers cholesterol coding connected damaging disordered displays exome functionally genomes harbour infarction inheritance ldl ldlr lipase lipoprotein lipoproteins mi namely rare refs sequenced synonymous triglyceride triglycerides	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Difference) ?		ago alleles apolipoprotein carriers cholesterol coding connected damaging disordered displays exome functionally genomes harbour infarction inheritance ldl ldlr lipase lipoprotein lipoproteins mi namely rare refs sequenced synonymous triglyceride triglycerides	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Intersection) ?