APOA5 and ACSF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOA5	ACSF2
Description		apolipoprotein A5	acyl-CoA synthetase family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Nucleotide Binding Catalytic Activity Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity
	Biological Process	Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Acylglycerol Homeostasis Triglyceride Homeostasis	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases		Hyperlipoproteinemia, type V
GWAS		Abdominal aortic aneurysm ( 32981348) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cardiovascular risk factors (age interaction) ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 20686565 26780889) Coronary artery disease ( 29212778 29263402 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 20686565 20864672 21347282 26582766 26780889 28371326 29212154) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 26690388 28334899 31694877) Hematocrit ( 29403010) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 33339817) Hypertriglyceridemia ( 20657596 23505323 27599772 31910446) LDL cholesterol ( 18179892 19060911 20686565 20864672) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24023260 24386095) Low HDL-cholesterol levels ( 31910446) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 21386085 28371326 29212154 30382898 31170924 31910446) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 22916037 23823483) Multiple sclerosis ( 31604244) NHDL cholesterol to HDL cholesterol ratio ( 28046027) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Platelet count ( 29403010) Postprandial triglyceride levels ( 32603185) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 29403010 29615537 30275531) Triacylglyceride levels ( 31551469) Triglyceride levels ( 26763881 28334899 28371326 29212154 29403010 29615537 30718733 32154731 32335043 33339817) Triglyceride levels in HIV infection ( 33109212) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 18193043 18193044 19060906 19060911 19074352 20139978 20686565 20864672 21909109 22171074 24097068 26160806 26582766 26780889 29404214) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)	Heel bone mineral density ( 30598549)
Interacting Genes		16 interacting genes: ACSF2 BMP10 CMTM3 CMTM5 CMTM6 FAS MORN4 MYG1 RAB5B SELENOS SMARCD1 TMEM120B TMEM19 TMEM43 TTPA YIF1A	19 interacting genes: AGTRAP APOA5 APOC1 ARL13B ARL6IP1 C10orf67 CLEC10A CMTM5 COQ9 CREB3 DGAT2L6 GPR152 MICOS13 RDH10 RHBDD2 SENP2 SIGLEC12 SYNGR3 USP40
Entrez ID		116519	80221
HPRD ID		06966	13380
Ensembl ID		ENSG00000110243	ENSG00000167107
Uniprot IDs		A0A0B4RUS7 Q6Q788	B4DTB9 E9PF16 Q96CM8
PDB IDs
Enriched GO Terms of Interacting Partners?			Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Clearance Acylglycerol Metabolic Process Chylomicron Neutral Lipid Metabolic Process Phospholipid Efflux Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Regulation Of Ketone Metabolic Process Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Protein-containing Complex Remodeling Lipoprotein Metabolic Process Phosphatidylcholine Binding Cholesterol Efflux Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Remodeling Negative Regulation Of Phosphatidylcholine Catabolic Process Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity Isoprenoid Binding Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Lipase Activator Activity Endoplasmic Reticulum Unfolded Protein Response Cholesterol Transport Regulation Of Phosphatidylcholine Catabolic Process Membrane Lipoprotein Particle Receptor Binding Lipoprotein Lipase Activator Activity Receptor Localization To Non-motile Cilium Acylglycerol Acyl-chain Remodeling Sterol Transport Alcohol Metabolic Process
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