APOA5

Gene Name		apolipoprotein A-V
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Blood Microparticle
	Molecular Function	Phospholipid Binding Enzyme Activator Activity Heparin Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Lipid Transport Response To Hormone Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Neuron Projection Regeneration Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Lipoprotein Lipase Activity Acylglycerol Homeostasis Triglyceride Homeostasis
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990 21347282) HDL cholesterol ( 20864672 19060906 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 21386085) Metabolite levels ( 22916037) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Response to Vitamin E supplementation ( 22437554) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 22171074 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Protein-protein Interactions		3 interactors: FAS RAB5B SMARCD1
Entrez ID		116519
HPRD ID		06966
Ensembl ID		ENSG00000110243
Uniprot IDs		Q6Q788
PDB IDs
Enriched GO Terms of Interacting Partners?		Motor Neuron Apoptotic Process Necroptotic Signaling Pathway Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Plasma Membrane To Endosome Transport Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Chromatin-mediated Maintenance Of Transcription Pantothenate Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Nucleosome Disassembly Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Response To Lithium Ion T Cell Apoptotic Process Positive Regulation Of Gene Expression, Epigenetic Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Regulation Of Protein Oligomerization Endosome Organization Response To Lithium Ion Necroptotic Process Response To Hyperoxia Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T Cell Selection Cellular Response To Interleukin-4 Spleen Development Triglyceride Biosynthetic Process Programmed Necrotic Cell Death Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Interleukin-4 Neuron Apoptotic Process Rab Protein Signal Transduction Immunoglobulin Production Acyl-CoA Metabolic Process Neuron Death T Cell Differentiation In Thymus Lymphocyte Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Tagcloud ?		ago alleles apolipoprotein carriers cholesterol coding connected damaging disordered displays exome functionally genomes harbour infarction inheritance ldl ldlr lipase lipoprotein lipoproteins mi namely rare refs sequenced synonymous triglyceride triglycerides