APOA5 and RAB5B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		APOA5	RAB5B
Description		apolipoprotein A5	RAB5B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicle	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding
	Biological Process	Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Acylglycerol Homeostasis Triglyceride Homeostasis	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases		Hyperlipoproteinemia, type V
GWAS		Abdominal aortic aneurysm ( 32981348) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cardiovascular risk factors (age interaction) ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 20686565 26780889) Coronary artery disease ( 29212778 29263402 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 20686565 20864672 21347282 26582766 26780889 28371326 29212154) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 26690388 28334899 31694877) Hematocrit ( 29403010) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 33339817) Hypertriglyceridemia ( 20657596 23505323 27599772 31910446) LDL cholesterol ( 18179892 19060911 20686565 20864672) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24023260 24386095) Low HDL-cholesterol levels ( 31910446) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 21386085 28371326 29212154 30382898 31170924 31910446) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 22916037 23823483) Multiple sclerosis ( 31604244) NHDL cholesterol to HDL cholesterol ratio ( 28046027) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Platelet count ( 29403010) Postprandial triglyceride levels ( 32603185) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 29403010 29615537 30275531) Triacylglyceride levels ( 31551469) Triglyceride levels ( 26763881 28334899 28371326 29212154 29403010 29615537 30718733 32154731 32335043 33339817) Triglyceride levels in HIV infection ( 33109212) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 18193043 18193044 19060906 19060911 19074352 20139978 20686565 20864672 21909109 22171074 24097068 26160806 26582766 26780889 29404214) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		16 interacting genes: ACSF2 BMP10 CMTM3 CMTM5 CMTM6 FAS MORN4 MYG1 RAB5B SELENOS SMARCD1 TMEM120B TMEM19 TMEM43 TTPA YIF1A	19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		116519	5869
HPRD ID		06966	01544
Ensembl ID		ENSG00000110243	ENSG00000111540
Uniprot IDs		A0A0B4RUS7 Q6Q788	P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?			Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport
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