BBS2 and MAP2K5

		BBS2	MAP2K5
Description		Bardet-Biedl syndrome 2	mitogen-activated protein kinase kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane	Spindle
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		BBSome-mediated cargo-targeting to cilium	Signalling to ERK5
Drugs			Fostamatinib Pimasertib
Diseases		Bardet-Biedl syndrome (BBS)
GWAS			Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 33239738 17637780 21779176 29029846) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC	56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620
Entrez ID		583	5607
HPRD ID		05855	03951
Ensembl ID		ENSG00000125124	ENSG00000137764
Uniprot IDs		A0A804HIE1 A0A804HKG1 Q9BXC9	Q13163
PDB IDs			2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?		Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center	Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding
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