BBS2 and KCNK17

		BBS2	KCNK17
Description		Bardet-Biedl syndrome 2	potassium two pore domain channel subfamily K member 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		BBSome-mediated cargo-targeting to cilium	TWIK-related alkaline pH activated K+ channel (TALK) Phase 4 - resting membrane potential
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS			Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068)
Interacting Genes		17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC	1 interacting genes: VKORC1
Entrez ID		583	89822
HPRD ID		05855	09566
Ensembl ID		ENSG00000125124	ENSG00000124780
Uniprot IDs		A0A804HIE1 A0A804HKG1 Q9BXC9	Q96T54
PDB IDs
Enriched GO Terms of Interacting Partners?		Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center	Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency BBSome Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Vascular Associated Smooth Muscle Contraction Striatum Development Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Regulation Of Response To Food Pigment Granule Localization Establishment Of Melanosome Localization Melanosome Localization Response To Leptin Brain Morphogenesis Melanosome Transport Pigment Granule Transport Regulation Of Appetite Sperm Axoneme Assembly Positive Regulation Of Coagulation Vasoconstriction Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Golgi To Plasma Membrane Protein Transport Regulation Of Cilium Movement Photoreceptor Cell Maintenance Stereocilium Smooth Muscle Contraction Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Axoneme Assembly Animal Organ Development Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Multicellular Organism Growth Microvillus Hippocampus Development Bone Development Positive Regulation Of Multicellular Organismal Process
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