BBS2 and BHMT

Number of citations: 0 (PubMedID 18000879)
Data Source: BioGRID (two hybrid)

		BBS2	BHMT
Name		Bardet-Biedl syndrome 2	betaine--homocysteine S-methyltransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage
Pathways		BBSome-mediated cargo-targeting to cilium	Sulfur amino acid metabolism Choline catabolism
Drugs		None	Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine
Diseases		Bardet-Biedl syndrome (BBS)	None
GWAS		No GWAS studies recorded	Betaine levels in individuals undergoing cardiac evaluation ( 26822151 ) Blood and toenail selenium levels ( 25343990 ) Blood trace element (Se levels) ( 23720494 ) Metabolite levels ( 23378610 23823483 ) Serum metabolite levels ( 33031748 ) Toenail selenium levels ( 25343990 )
Interacting Genes		17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		583	635
HPRD ID		05855	04200
Ensembl ID		ENSG00000125124	ENSG00000145692
Uniprot IDs		A0A804HIE1 A0A804HKG1 Q9BXC9	Q93088 V9HWA4
PDB IDs		Not available	1LT7 1LT8 4M3P 8D45
GO Terms Enriched among Interactors		Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center	BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling