POLR1D and E2F4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		POLR1D	E2F4
Description		RNA polymerase I and III subunit D	E2F transcription factor 4
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol Nuclear DNA-directed RNA Polymerase Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase III	Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Regulation Of Cell Size Animal Organ Morphogenesis Cell Projection Organization Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases		Treacher Collins syndrome
GWAS		Body mass index ( 26426971)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: CDC25A CEBPA CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN	34 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RECQL RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRIM33 TRRAP USP2 XPO1
Entrez ID		51082	1874
HPRD ID		17877	02806
Ensembl ID		ENSG00000186184	ENSG00000205250
Uniprot IDs		A0A087WTY1 P0DPB5 P0DPB6	Q16254
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	1CF7 5TUU
Enriched GO Terms of Interacting Partners?		CHOP-C/EBP Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Protein Domain Specific Binding Regulation Of RNA Biosynthetic Process Protein-folding Chaperone Binding Transcription By RNA Polymerase I Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression ATPase Activator Activity Nucleoplasm Cytoplasm Regulation Of Primary Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cortex Integrated Stress Response Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Dexamethasone Macrophage Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Xenobiotic Stimulus Gland Development Negative Regulation Of Biosynthetic Process Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Lipid Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Positive Regulation Of Metabolic Process Co-SMAD Binding Chromatin Organization DNA Binding Regulation Of Cell Cycle Process IkappaB Kinase Activity Paraxial Mesoderm Morphogenesis Promoter-specific Chromatin Binding R-SMAD Binding Cell Differentiation BHLH Transcription Factor Binding Ubiquitin Protein Ligase Binding Mesoderm Morphogenesis Rb-E2F Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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