PURB and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		PURB	IL7R
Gene Name		purine-rich element binding protein B	interleukin 7 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity MRNA Binding Transcription Factor Binding Poly(A) RNA Binding SMAD Binding	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways			Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		3 interactors: CSNK2A1 IL7R PURA	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		5814	3575
HPRD ID		12325	00893
Ensembl ID		ENSG00000146676	ENSG00000168685
Uniprot IDs		Q96QR8	D6RGV2 D9N160 P16871
PDB IDs			3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Interleukin-7-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Immunity DNA Unwinding Involved In DNA Replication Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Protein Metabolic Process DNA Replication Initiation Negative Regulation Of Adaptive Immune Response Mitotic Spindle Checkpoint B Cell Proliferation Negative Regulation Of Chromosome Segregation System Development Cell Morphogenesis Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Immunoglobulin Production Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Multicellular Organismal Development Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process DNA Duplex Unwinding DNA Geometric Change Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Translation Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Chromosome Organization Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Differentiation	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		5q31 7p13 aml balance bands chromosomes concurrent cooperative del deleted deletions delicate egr functionally hemizygously heterodimers localizes mapping monosomy myelogenous nearly pura q31 segment segregation simultaneous telomeric	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		5q31 7p13 aml balance bands chromosomes concurrent cooperative del deleted deletions delicate egr functionally hemizygously heterodimers localizes mapping monosomy myelogenous nearly pura q31 segment segregation simultaneous telomeric	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?