PURB and MIR31

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PURB	MIR31
Description		purine rich element binding protein B	microRNA 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Space RISC Complex Microvesicle
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding	MRNA 3'-UTR Binding Protein Binding MRNA Base-pairing Post-transcriptional Repressor Activity MRNA CDS Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translation Regulation Of Myeloid Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Interleukin-34 Production Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Amyloid Fibril Formation
Pathways
Drugs
Diseases
GWAS		Platelet count ( 27863252)
Interacting Genes		25 interacting genes: AP1M1 CEBPA CSNK2A1 IL7R LNX1 MBD2 MIR128-1 MIR128-2 MIR25 MIR29C MIR31 MIR34B MIR363 MIR7-1 MIR7-3 MIR9-2 MIRLET7A3 MIRLET7G MIRLET7I NABP1 NXF1 PCDHB14 PURA RBFOX2 ZNF497	83 interacting genes: ADARB1 AIMP1 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 EIF2AK2 EPRS1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MYEF2 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PTBP1 PTBP3 PUF60 PURA PURB QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		5814	407035
HPRD ID		12325
Ensembl ID		ENSG00000146676	ENSG00000199177
Uniprot IDs		Q96QR8
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Regulation Of Macromolecule Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Protein Metabolic Process Regulation Of Cardiac Muscle Hypertrophy In Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Vasculature Development Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Lipoprotein Transport MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-34 Production Negative Regulation Of Cell Cycle Negative Regulation Of Locomotion Regulation Of Cell Population Proliferation	RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Processing RNA Splicing Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleoplasm Spliceosomal Complex Aminoacyl-tRNA Synthetase Multienzyme Complex Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Cytoplasmic Stress Granule Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization MiRNA Binding TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Regulation Of RNA Stability MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process TRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Metabolic Process Positive Regulation Of Gene Expression
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