PURB

Description		purine rich element binding protein B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translation Regulation Of Myeloid Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Platelet count ( 27863252)
Interacting Genes		25 interacting genes: AP1M1 CEBPA CSNK2A1 IL7R LNX1 MBD2 MIR128-1 MIR128-2 MIR25 MIR29C MIR31 MIR34B MIR363 MIR7-1 MIR7-3 MIR9-2 MIRLET7A3 MIRLET7G MIRLET7I NABP1 NXF1 PCDHB14 PURA RBFOX2 ZNF497
Entrez ID		5814
HPRD ID		12325
Ensembl ID		ENSG00000146676
Uniprot IDs		Q96QR8
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Regulation Of Macromolecule Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Protein Metabolic Process Regulation Of Cardiac Muscle Hypertrophy In Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Vasculature Development Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Lipoprotein Transport MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-34 Production Negative Regulation Of Cell Cycle Negative Regulation Of Locomotion Regulation Of Cell Population Proliferation
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