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COL1A1 and DCN
Number of citations of the paper that reports this interaction (PubMedID
9675033
)
0
Data Source:
HPRD
(in vitro)
COL1A1
DCN
Description
collagen type I alpha 1 chain
decorin
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Secretory Granule
Extracellular Matrix
Extracellular Region
Extracellular Space
Golgi Lumen
Extracellular Matrix
Lysosomal Lumen
Molecular Function
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
RNA Binding
Protein Binding
Glycosaminoglycan Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Extracellular Matrix Binding
Biological Process
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Response To Nutrient
Visual Perception
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Nutrient Levels
Response To Estradiol
Response To Insulin
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of DNA-templated Transcription
Animal Organ Development
Response To Steroid Hormone
Skeletal System Morphogenesis
Embryonic Skeletal System Development
System Development
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Response To Fluoride
Cellular Response To Fluoride
Animal Organ Morphogenesis
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Macroautophagy
Negative Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Degradation of the extracellular matrix
Glycosaminoglycan-protein linkage region biosynthesis
CS-GAG biosynthesis
DS-GAG biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog alfa
Von Willebrand factor human
Diseases
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Keratoconus (
33649486
)
Response to taxane treatment (docetaxel) (
23006423
)
Blood protein levels (
30072576
)
Central corneal thickness (
29760442
32528159
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Sudden cardiac arrest (
21658281
)
Interacting Genes
44 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL18A1
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
LAIR1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
TGM2
THBS1
TMPRSS6
TNFAIP3
TXN
UBC
VWF
32 interacting genes:
ADARB1
AHSG
BRCA1
C1QA
CCN4
COL14A1
COL1A1
COL1A2
COL4A1
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
DPT
EGFR
ELN
FBN1
FLNA
FN1
MET
MMP2
MMP3
MMP7
PLA2G2A
SF1
SFTPD
TGFB1
TGFB2
THBS1
TNF
Entrez ID
1277
1634
HPRD ID
00362
00501
Ensembl ID
ENSG00000108821
ENSG00000011465
Uniprot IDs
P02452
P07585
Q6FH10
PDB IDs
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
7E7B
7E7D
Enriched GO Terms of Interacting Partners
?
Collagen Binding
Extracellular Matrix
Extracellular Region
Extracellular Matrix Structural Constituent
Extracellular Space
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Extracellular Matrix Binding
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Extracellular Structure Organization
Extracellular Matrix Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Response To Wounding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Locomotion
Developmental Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Cell-matrix Adhesion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Endodermal Cell Differentiation
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Cell-substrate Adhesion
Extracellular Exosome
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Signaling
Integrin Binding
Regulation Of Developmental Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Adhesion
Cell Surface
Regulation Of MAPK Cascade
Endoplasmic Reticulum Lumen
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Extracellular Matrix
Extracellular Region
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent
Collagen Trimer
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Endoplasmic Reticulum Lumen
Cellular Response To Amino Acid Stimulus
Basement Membrane
Collagen Type IV Trimer
Response To Amino Acid
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Platelet-derived Growth Factor Binding
Extracellular Space
Collagen Fibril Organization
Collagen Metabolic Process
Collagen-activated Signaling Pathway
Cell Adhesion
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Cell Motility
Animal Organ Morphogenesis
Regulation Of Locomotion
Regulation Of Smooth Muscle Cell Proliferation
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Animal Organ Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Platelet Alpha Granule Lumen
Extracellular Matrix Assembly
Integrin Binding
Face Morphogenesis
Tissue Development
Negative Regulation Of Cell Population Proliferation
Fibrillar Collagen Trimer
Positive Regulation Of Smooth Muscle Cell Proliferation
Salivary Gland Morphogenesis
Response To Xenobiotic Stimulus
Cell Morphogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Adhesion
Response To Mechanical Stimulus
Protease Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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