COL1A1 and TGFBI

Number of citations of the paper that reports this interaction (PubMedID 12034705)
0

Data Source:
HPRD (in vitro)

		COL1A1	TGFBI
Description		collagen type I alpha 1 chain	transforming growth factor beta induced
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Secretory Granule Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Exosome Cell Periphery
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Identical Protein Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Response To Nutrient Visual Perception Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Nutrient Levels Response To Estradiol Response To Insulin Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of DNA-templated Transcription Animal Organ Development Response To Steroid Hormone Skeletal System Morphogenesis Embryonic Skeletal System Development System Development Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Response To Fluoride Cellular Response To Fluoride	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Population Proliferation Extracellular Matrix Organization
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells	Amyloid fiber formation
Drugs		Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog alfa Von Willebrand factor human
Diseases		Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease	Reis-Bucklers corneal dystrophy (RBCD); Corneal dystrophy of Bowman's type I; Granular corneal dystrophy type III Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Thiel-Behnke dystrophies (TBCD); Corneal dystrophy of Bowman layer type II; Honeycomb corneal dystrophy; Anterior limiting membrane dystrophy type II; Curly fibers corneal dystrophy; Waardenburg-Jonker corneal dystrophy Granular corneal dystrophies (GCD), including: Corneal dystrophy Groenouw type I; Avellino corneal dystrophy; Granular-lattice dystrophy
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Response to taxane treatment (docetaxel) ( 23006423)	Blood protein levels ( 30072576) Insomnia ( 27992416) Response to cytidine analogues (gemcitabine) ( 24483146) Stroke ( 26089329)
Interacting Genes		44 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL18A1 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 LAIR1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI TGM2 THBS1 TMPRSS6 TNFAIP3 TXN UBC VWF	15 interacting genes: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FBXL17 FN1 LINC00632 LINC01554 MMP9 S100P
Entrez ID		1277	7045
HPRD ID		00362	03409
Ensembl ID		ENSG00000108821	ENSG00000120708
Uniprot IDs		P02452	A0A0S2Z4Q2 Q15582
PDB IDs		1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9 7E7B 7E7D	1X3B 2LTB 2LTC 2VXP 5NV6 7AS7 7ASC 7ASG 8HGA 8HIA
Enriched GO Terms of Interacting Partners?		Collagen Binding Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Space Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Extracellular Matrix Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Cell Motility Response To Wounding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Locomotion Developmental Process Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Cell-matrix Adhesion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Endodermal Cell Differentiation Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell-substrate Adhesion Extracellular Exosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Signaling Integrin Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Cell Surface Regulation Of MAPK Cascade Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Organization Extracellular Structure Organization Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Basement Membrane Collagen-activated Signaling Pathway Fibrillar Collagen Trimer Extracellular Region Collagen Type I Trimer Protease Binding Endodermal Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Skeletal System Development Collagen Fibril Organization Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cellular Response To Amino Acid Stimulus Skin Morphogenesis Proteoglycan Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Amino Acid Cell Surface Receptor Signaling Pathway Developmental Process System Development Sensory Perception Of Sound Endochondral Ossification Sensory Perception Of Mechanical Stimulus Cellular Developmental Process Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Vitamin E Protein Heterotrimerization Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Extracellular Space Cellular Response To Transforming Growth Factor Beta Stimulus Platelet Alpha Granule Lumen Collagen Binding Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Fluoride Nitric Oxide Catabolic Process
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