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COL1A1 and ITGA5
Number of citations of the paper that reports this interaction (PubMedID
1693626
)
32
Data Source:
HPRD
(in vitro, in vivo)
COL1A1
ITGA5
Description
collagen type I alpha 1 chain
integrin subunit alpha 5
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Secretory Granule
Extracellular Matrix
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Postsynaptic Membrane
Anchoring Junction
Alphav-beta3 Integrin-vitronectin Complex
Glutamatergic Synapse
Molecular Function
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Virus Receptor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Response To Nutrient
Visual Perception
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Nutrient Levels
Response To Estradiol
Response To Insulin
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of DNA-templated Transcription
Animal Organ Development
Response To Steroid Hormone
Skeletal System Morphogenesis
Embryonic Skeletal System Development
System Development
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Response To Fluoride
Cellular Response To Fluoride
Angiogenesis
Formation Of Primary Germ Layer
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Tissue Development
Positive Regulation Of Cell-substrate Adhesion
Response To Muscle Activity
CD40 Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Regulation Of Angiogenesis
Symbiont Entry Into Host Cell
Cell-cell Adhesion
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Pathways
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
GPER1 signaling
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog alfa
Von Willebrand factor human
Resveratrol
Tauroursodeoxycholic acid
Diseases
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
GWAS
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Keratoconus (
33649486
)
Response to taxane treatment (docetaxel) (
23006423
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
44 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL18A1
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
LAIR1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
TGM2
THBS1
TMPRSS6
TNFAIP3
TXN
UBC
VWF
32 interacting genes:
ACKR5
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
VTN
Entrez ID
1277
3678
HPRD ID
00362
00627
Ensembl ID
ENSG00000108821
ENSG00000161638
Uniprot IDs
P02452
B2R627
P08648
PDB IDs
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
7E7B
7E7D
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
7NWL
7NXD
9B9J
9B9K
9CKV
Enriched GO Terms of Interacting Partners
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Collagen Binding
Extracellular Matrix
Extracellular Region
Extracellular Matrix Structural Constituent
Extracellular Space
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Extracellular Matrix Binding
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Extracellular Structure Organization
Extracellular Matrix Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Response To Wounding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Locomotion
Developmental Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Cell-matrix Adhesion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Endodermal Cell Differentiation
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Cell-substrate Adhesion
Extracellular Exosome
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Signaling
Integrin Binding
Regulation Of Developmental Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Adhesion
Cell Surface
Regulation Of MAPK Cascade
Endoplasmic Reticulum Lumen
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Adhesion
Integrin Binding
Cell-substrate Adhesion
Cell-matrix Adhesion
Regulation Of Cell Migration
Regulation Of Cell Motility
Regulation Of Locomotion
Angiogenesis
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cell Migration
Extracellular Matrix
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Cell Migration
Receptor Complex
Response To Growth Factor
Signal Transduction
Cell Adhesion Mediated By Integrin
Enzyme-linked Receptor Protein Signaling Pathway
Cell Motility
Extracellular Exosome
Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Response To Wounding
Regulation Of ERK1 And ERK2 Cascade
Focal Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Extracellular Space
Negative Regulation Of Blood Coagulation
Cell Junction Organization
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Activity
Mesodermal Cell Differentiation
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Extracellular Region
Regulation Of Cell-substrate Adhesion
Regulation Of Anatomical Structure Morphogenesis
Platelet Alpha Granule Membrane
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Wound Healing
Regulation Of Cell Population Proliferation
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Tagcloud (Intersection)
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