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COL1A1 and MMP9
Number of citations of the paper that reports this interaction (PubMedID
9878537
)
0
Data Source:
HPRD
(in vivo)
COL1A1
MMP9
Description
collagen type I alpha 1 chain
matrix metallopeptidase 9
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Secretory Granule
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Tertiary Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Collagen Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Response To Nutrient
Visual Perception
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Nutrient Levels
Response To Estradiol
Response To Insulin
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of DNA-templated Transcription
Animal Organ Development
Response To Steroid Hormone
Skeletal System Morphogenesis
Embryonic Skeletal System Development
System Development
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Response To Fluoride
Cellular Response To Fluoride
Skeletal System Development
Positive Regulation Of Protein Phosphorylation
Proteolysis
Apoptotic Process
Embryo Implantation
Cell Migration
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Macrophage Differentiation
Collagen Catabolic Process
Endodermal Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Positive Regulation Of Keratinocyte Migration
Cellular Response To Lipopolysaccharide
Cellular Response To UV-A
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Neuroinflammatory Response
Negative Regulation Of Cation Transmembrane Transport
Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Signaling by SCF-KIT
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EPH-ephrin mediated repulsion of cells
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Extra-nuclear estrogen signaling
Drugs
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog alfa
Von Willebrand factor human
Glutathione
Marimastat
Minocycline
Captopril
Zinc
2-Amino-N,3,3-Trimethylbutanamide
2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid
AE-941
PG-530742
Endostatin
5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE
(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE
(3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Oleandrin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
Penile cancer
Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Keratoconus (
33649486
)
Response to taxane treatment (docetaxel) (
23006423
)
Abdominal aortic aneurysm (
27899403
)
Advanced age-related macular degeneration (
26691988
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Coronary artery disease (
33020668
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
23128233
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Mild influenza (H1N1) infection (
26379185
)
Systemic sclerosis (
29293537
)
Interacting Genes
44 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL18A1
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
LAIR1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
TGM2
THBS1
TMPRSS6
TNFAIP3
TXN
UBC
VWF
32 interacting genes:
AREG
BTC
CD44
COL1A1
COL1A2
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
CXCL1
CXCL5
CXCL6
CXCL8
EPHB2
FN1
HAPLN1
KISS1
LCN2
MMP10
MMP26
MMP7
PLG
PRSS2
PZP
RECK
TFPI
TGFBI
THBS1
THBS2
TIMP3
Entrez ID
1277
4318
HPRD ID
00362
00387
Ensembl ID
ENSG00000108821
ENSG00000100985
Uniprot IDs
P02452
P14780
PDB IDs
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
7E7B
7E7D
1GKC
1GKD
1ITV
1L6J
2OVX
2OVZ
2OW0
2OW1
2OW2
4H1Q
4H2E
4H3X
4H82
4HMA
4JIJ
4JQG
4WZV
4XCT
5CUH
5I12
5TH6
5TH9
5UE3
5UE4
6ESM
8K5V
8K5W
8K5X
8K5Y
Enriched GO Terms of Interacting Partners
?
Collagen Binding
Extracellular Matrix
Extracellular Region
Extracellular Matrix Structural Constituent
Extracellular Space
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Extracellular Matrix Binding
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Extracellular Structure Organization
Extracellular Matrix Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Response To Wounding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Locomotion
Developmental Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Cell-matrix Adhesion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Endodermal Cell Differentiation
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Cell-substrate Adhesion
Extracellular Exosome
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Signaling
Integrin Binding
Regulation Of Developmental Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Adhesion
Cell Surface
Regulation Of MAPK Cascade
Endoplasmic Reticulum Lumen
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Extracellular Region
Extracellular Matrix
Extracellular Matrix Structural Constituent
Extracellular Space
Extracellular Matrix Organization
Extracellular Structure Organization
Collagen Type IV Trimer
Basement Membrane
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Collagen Trimer
Endoplasmic Reticulum Lumen
Protease Binding
Collagen Metabolic Process
Angiogenesis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Antimicrobial Humoral Response
Collagen Catabolic Process
Platelet-derived Growth Factor Binding
Cell Surface Receptor Signaling Pathway
Endopeptidase Inhibitor Activity
CXCR Chemokine Receptor Binding
Extracellular Matrix Disassembly
Peptidase Inhibitor Activity
Metalloendopeptidase Inhibitor Activity
Chemokine Activity
Response To Amino Acid
Regulation Of Anatomical Structure Morphogenesis
Collagen Type I Trimer
Inflammatory Response
Positive Regulation Of Cell Migration
Humoral Immune Response
Regulation Of Blood Coagulation
Positive Regulation Of Cell Motility
Regulation Of Hemostasis
Heparin Binding
Response To Lipid
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Locomotion
Signal Transduction
Regulation Of Cell Adhesion
Anatomical Structure Formation Involved In Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Lipopolysaccharide
Serine-type Endopeptidase Inhibitor Activity
Cellular Response To Lipid
Cellular Response To Fibroblast Growth Factor Stimulus
Defense Response
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Tagcloud (Intersection)
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