COL1A1 and HTRA1

Number of citations of the paper that reports this interaction (PubMedID 15101818)
30

Data Source:
HPRD (two hybrid)

		COL1A1	HTRA1
Description		collagen type I alpha 1 chain	HtrA serine peptidase 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Secretory Granule Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity
	Biological Process	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Response To Nutrient Visual Perception Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Nutrient Levels Response To Estradiol Response To Insulin Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of DNA-templated Transcription Animal Organ Development Response To Steroid Hormone Skeletal System Morphogenesis Embryonic Skeletal System Development System Development Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Response To Fluoride Cellular Response To Fluoride	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix
Drugs		Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog alfa Von Willebrand factor human
Diseases		Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Response to taxane treatment (docetaxel) ( 23006423)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 33020668 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30804560 30061609) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Systolic blood pressure ( 30578418 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		44 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL18A1 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 LAIR1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI TGM2 THBS1 TMPRSS6 TNFAIP3 TXN UBC VWF	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		1277	5654
HPRD ID		00362	03725
Ensembl ID		ENSG00000108821	ENSG00000166033
Uniprot IDs		P02452	Q92743
PDB IDs		1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9 7E7B 7E7D	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8
Enriched GO Terms of Interacting Partners?		Collagen Binding Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Space Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Extracellular Matrix Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Cell Motility Response To Wounding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Locomotion Developmental Process Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Cell-matrix Adhesion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Endodermal Cell Differentiation Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell-substrate Adhesion Extracellular Exosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Signaling Integrin Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Cell Surface Regulation Of MAPK Cascade Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway
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