LSM2 and DDX20

Number of citations of the paper that reports this interaction (PMID 10601333)
62

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LSM2	DDX20
Gene Name		LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Transcriptional Repressor Complex SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Protein Binding U6 SnRNA Binding Ral GTPase Binding Protein Kinase Binding Poly(A) RNA Binding	DNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly RNA Processing Gene Expression NcRNA Metabolic Process Positive Regulation Of Apoptotic Process Oogenesis Regulation Of Steroid Biosynthetic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AES BANP C14orf1 CLNS1A CRMP1 DDX20 DNAJA1 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TRIM54 ZBTB16 ZNF408	31 interactors: AGO2 APP CRYAB DHX9 ETV3 GEMIN2 GEMIN4 GEMIN5 HDAC2 HDAC5 LSM2 NCOR1 NCOR2 NR0B2 PRRC2A RN7SL1 RNU1-1 RNU2-1 SIN3A SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN STXBP2 STXBP3
Entrez ID		57819	11218
HPRD ID		06282	05859
Ensembl ID		ENSG00000204392	ENSG00000064703
Uniprot IDs		Q9Y333	Q9H4N4 Q9UHI6
PDB IDs			2OXC 3B7G
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Metabolic Process MRNA Processing RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Ribonucleoprotein Complex Assembly RNA Catabolic Process NcRNA Metabolic Process Aromatic Compound Catabolic Process Histone MRNA Catabolic Process Spliceosomal Complex Assembly Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Macromolecular Complex Assembly Metabolic Process Termination Of RNA Polymerase II Transcription Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Catabolic Process DNA-templated Transcription, Termination Transcription From RNA Polymerase II Promoter MRNA 3'-end Processing Membrane Raft Localization Positive Regulation Of Anoikis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Embryonic Pattern Specification Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Cell Death Male Germ-line Stem Cell Asymmetric Division Somite Specification	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Ribonucleoprotein Complex Assembly MRNA Metabolic Process RNA Processing RNA Splicing Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Gene Expression NcRNA Metabolic Process Cellular Macromolecular Complex Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Component Assembly Cellular Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription RNA 3'-end Processing Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Termination Cellular Metabolic Process Transcription, DNA-templated Notch Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Neutrophil Degranulation Histone Deacetylation Protein Deacetylation Cellular Macromolecule Biosynthetic Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H4 Deacetylation Gene Silencing Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	acting box coactivators concentrate corepressors creb ddx17 ddx5 deacetylases dexd dhx9 dissociate dp103 helicase helicases hydrolysis includes machinery members modulation multifunctional p68 p72 require rna roles shall unwind unwindases
Tagcloud (Difference) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	acting box coactivators concentrate corepressors creb ddx17 ddx5 deacetylases dexd dhx9 dissociate dp103 helicase helicases hydrolysis includes machinery members modulation multifunctional p68 p72 require rna roles shall unwind unwindases
Tagcloud (Intersection) ?