DDX20 and SNRPD1

Number of citations of the paper that reports this interaction (PubMedID 10601333)
63

Data Source:
HPRD (in vitro, in vivo)

		DDX20	SNRPD1
Description		DEAD-box helicase 20	small nuclear ribonucleoprotein D1 polypeptide
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Nuclear Body Transcription Repressor Complex SMN Complex Protein-containing Complex SMN-Sm Protein Complex RNA Polymerase II Transcription Repressor Complex Gemini Of Cajal Bodies	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Histone Deacetylase Binding DNA-binding Transcription Factor Binding	RNA Binding Protein Binding U1 SnRNP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly RNA Processing MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Oogenesis Regulation Of Steroid Biosynthetic Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Body mass index ( 29273807) Metabolite levels ( 23823483) Venous thromboembolism ( 32232851)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: AGO2 APP CFTR CRYAB DHX9 ETV3 GEMIN2 GEMIN4 GEMIN5 HDAC2 HDAC5 NCOR1 NCOR2 NR0B2 NUFIP1 PRRC2A RN7SL1 RNU1-1 RNU2-1 SIN3A SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN STXBP2 STXBP3 TP53	19 interacting genes: CEBPA CLNS1A DDX20 ERCC6 FOXP1 GEMIN2 GEMIN4 GEMIN5 IL7R LSM8 PRMT5 PTEN SMN1 SMN2 SNRPB SNRPD2 SREK1 U2AF1 WDR77
Entrez ID		11218	6632
HPRD ID		05859	03040
Ensembl ID		ENSG00000064703	ENSG00000167088
Uniprot IDs		Q9H4N4 Q9UHI6	P62314
PDB IDs		2OXC 3B7G	1B34 3CW1 3JCR 3PGW 4F7U 4PJO 4V98 4WZJ 5MQF 5O9Z 5XJC 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9E3B 9E3C 9FMD 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex U4 SnRNP Methylosome Protein-containing Complex Assembly U2 SnRNP Protein-containing Complex Organization RNA Splicing, Via Transesterification Reactions U1 SnRNP U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex RNA Splicing U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome PICln-Sm Protein Complex U7 SnRNP MRNA Processing U4/U6 X U5 Tri-snRNP Complex MRNA Metabolic Process U2-type Precatalytic Spliceosome Cellular Component Assembly SMN Complex RNA Processing Gemini Of Cajal Bodies Nucleoplasm MRNA Splicing, Via Spliceosome RNA Methylation Precatalytic Spliceosome Catalytic Step 2 Spliceosome RNA Binding Spliceosomal Complex Macromolecule Methylation RNA Metabolic Process RNA Modification Nucleus Nuclear Body Ribonucleoprotein Complex Methylation Protein-containing Complex Spliceosomal Tri-snRNP Complex Transcription Repressor Complex Nucleic Acid Metabolic Process Rhythmic Process Cytosol Histone Deacetylase Complex	Spliceosomal SnRNP Assembly SMN-Sm Protein Complex Protein-RNA Complex Assembly RNA Splicing SMN Complex Gemini Of Cajal Bodies MRNA Processing RNA Metabolic Process MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Methylosome RNA Processing Nucleic Acid Metabolic Process Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Macromolecule Metabolic Process Protein-containing Complex Assembly Protein-containing Complex Organization MRNA Splicing, Via Spliceosome Nuclear Body Nucleus Small Nuclear Ribonucleoprotein Complex Cajal Body Cellular Component Assembly DNA-templated Transcription Termination Positive Regulation Of MRNA Splicing, Via Spliceosome U4/U6 X U5 Tri-snRNP Complex RNA Binding Positive Regulation Of RNA Splicing PICln-Sm Protein Complex U2-type Precatalytic Spliceosome 7-methylguanosine Cap Hypermethylation Endothelial Cell Activation U4 SnRNP Regulation Of Cell Size Catalytic Step 2 Spliceosome U1 SnRNP Precatalytic Spliceosome Positive Regulation Of Gene Expression U5 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Methylation U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Methyl-CpG Binding Regulation Of MRNA Processing U2-type Spliceosomal Complex
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