DAB1 and PAFAH1B1

Number of citations of the paper that reports this interaction (PMID 14578885)
50

Data Source:
HPRD (in vivo)

		DAB1	PAFAH1B1
Gene Name		Dab, reelin signal transducer, homolog 1 (Drosophila)	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cell Cortex Axon Growth Cone Cell Leading Edge Motile Primary Cilium Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol 3-kinase Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Protein Homodimerization Activity Phospholipase Binding Dynein Binding Dynein Intermediate Chain Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Organelle Organization Microtubule-based Process Mitotic Nuclear Division Nuclear Migration Synaptic Transmission Neuroblast Proliferation Learning Or Memory Retrograde Axon Cargo Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Regulation Of Rho GTPase Activity Osteoclast Development Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Nuclear Envelope Disassembly Establishment Of Centrosome Localization
Pathways			Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488	22 interactors: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DISC1 DNAI1 HSPH1 KARS KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		1600	5048
HPRD ID		04582	03329
Ensembl ID		ENSG00000173406	ENSG00000007168
Uniprot IDs		O75553	P43034
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration	Microtubule-based Process Microtubule Cytoskeleton Organization Mitotic Cell Cycle Process Mitotic Nuclear Division Mitotic Cell Cycle Nervous System Development Neuron Migration Cell Cycle Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Regulation Of Neuron Projection Development Generation Of Neurons Organelle Localization Neurogenesis Microtubule Bundle Formation Cytoskeleton-dependent Intracellular Transport Cell Cycle Multicellular Organismal Development Regulation Of Cell Projection Organization System Development Establishment Of Organelle Localization Regulation Of Neuron Differentiation Organelle Organization Developmental Process Central Nervous System Development Anatomical Structure Development Regulation Of Neurogenesis Cellular Localization Brain Development G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cell Projection Organization Head Development Cell Migration Microtubule-based Movement Regulation Of Cell Development Dendrite Development Locomotion Establishment Of Chromosome Localization Cell Motility Cell Differentiation Cerebral Cortex Development Organelle Transport Along Microtubule Neuron Projection Extension Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Establishment Of Vesicle Localization Mitotic Centrosome Separation Microtubule Severing
Tagcloud ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Difference) ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Intersection) ?		lis1 lissencephaly