DAB1 and RELN

Number of citations of the paper that reports this interaction (PMID 11137154)
11

Data Source:
HPRD (in vivo)

		DAB1	RELN
Gene Name		Dab, reelin signal transducer, homolog 1 (Drosophila)	reelin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Dendrite
	Molecular Function	Phosphatidylinositol 3-kinase Binding	Protein Serine/threonine/tyrosine Kinase Activity Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Long-term Memory Associative Learning Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Dendrite Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Positive Regulation Of TOR Signaling Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Regulation Of Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation N-methyl-D-aspartate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)	Alzheimer's disease ( 20452100) Multiple sclerosis (age of onset) ( 19010793) Otosclerosis ( 19230858) Schizophrenia ( 18282107)
Protein-Protein Interactions		73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488	6 interactors: DAB1 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR
Entrez ID		1600	5649
HPRD ID		04582	02742
Ensembl ID		ENSG00000173406	ENSG00000189056
Uniprot IDs		O75553	P78509
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration	Reelin-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Nervous System Development Positive Regulation Of Neuron Differentiation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Projection Development Ventral Spinal Cord Development Positive Regulation Of Dendrite Development Positive Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Cerebral Cortex Radially Oriented Cell Migration Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Developmental Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Cerebral Cortex Cell Migration Regulation Of Neuron Differentiation Positive Regulation Of Transferase Activity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Ammon Gyrus Development Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development Spinal Cord Development Regulation Of Neurogenesis Cerebellum Structural Organization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Development Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Very-low-density Lipoprotein Particle Clearance Glycoprotein Transport Regulation Of Cell Development Positive Regulation Of Cell Differentiation System Development Regulation Of Protein Metabolic Process Spinal Cord Motor Neuron Migration Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Pallium Development Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Development
Tagcloud ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical	ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler reelin repeats rule splice successive symbol tandemly tata
Tagcloud (Difference) ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial retzius tangential tbr thalamocortical	ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler repeats rule splice successive symbol tandemly tata
Tagcloud (Intersection) ?		reelin