DAB1 and TMTC3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DAB1	TMTC3
Description		DAB adaptor protein 1	transmembrane O-mannosyltransferase targeting cadherins 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Signaling Adaptor Activity	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Protein Binding Transferase Activity
	Biological Process	Neuron Migration Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Hippocampus Development Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Regulation Of Synapse Maturation Motor Neuron Migration Lateral Motor Column Neuron Migration Radial Glia-guided Pyramidal Neuron Migration	Protein Glycosylation Response To Endoplasmic Reticulum Stress Protein O-linked Glycosylation Via Mannose Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Reelin signalling pathway
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age at first sexual intercourse ( 34211149) Alzheimer's disease progression score ( 29860282) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Cardiac troponin-I levels ( 31014085) Coronary artery disease ( 29472232) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Immune reponse to smallpox (secreted IL-10) ( 22610502) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Kawasaki disease ( 21221998) Lateral orbital frontal cortex volume ( 31530798) Logical memory (delayed recall) in normal cognition ( 29274321) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Pubertal anthropometrics ( 23449627) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196) White matter hyperintensities in ischemic stroke ( 26674333)	Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		76 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488	1 interacting genes: DAB1
Entrez ID		1600	160418
HPRD ID		04582	10243
Ensembl ID		ENSG00000173406	ENSG00000139324
Uniprot IDs		O75553	A8K321 Q6ZXV5
PDB IDs
Enriched GO Terms of Interacting Partners?		Reelin-mediated Signaling Pathway Receptor Complex Layer Formation In Cerebral Cortex Cellular Response To Growth Factor Stimulus Low-density Lipoprotein Particle Receptor Activity Response To Growth Factor Cell Surface Receptor Signaling Pathway Clathrin-coated Pit Enzyme-linked Receptor Protein Signaling Pathway Cargo Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Dendrite Development Neuron Projection Morphogenesis Very-low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Endocytosis Regulation Of Macromolecule Metabolic Process Apolipoprotein Binding Hippocampus Development ErbB-3 Class Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Forebrain Development Regulation Of Gene Expression Cerebral Cortex Development System Development Positive Regulation Of Protein Catabolic Process In The Vacuole Negative Regulation Of Leukocyte Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Postsynaptic Specialization Organization Negative Regulation Of Immune System Process Ventral Spinal Cord Development Anatomical Structure Morphogenesis Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Integrin-mediated Signaling Pathway Integrin Complex Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Activation Regulation Of Synapse Organization Receptor Tyrosine Kinase Binding Nervous System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Glial Cell Development Protein Binding Regulation Of Cell Motility Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Regulation Of Lysosomal Protein Catabolic Process	Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Radial Glia-guided Pyramidal Neuron Migration Ventral Spinal Cord Development Negative Regulation Of Astrocyte Differentiation Cell Migration In Hindbrain Golgi Localization Reelin-mediated Signaling Pathway Motor Neuron Migration Layer Formation In Cerebral Cortex Anatomical Structure Arrangement Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Differentiation Regulation Of Astrocyte Differentiation Adult Walking Behavior Cerebral Cortex Cell Migration Negative Regulation Of Glial Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Synapse Maturation Walking Behavior Telencephalon Cell Migration Negative Regulation Of Gliogenesis Dendrite Development Forebrain Cell Migration Negative Regulation Of Axonogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Glial Cell Differentiation Hippocampus Development Cell Surface Receptor Signaling Pathway Via JAK-STAT Adult Locomotory Behavior Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Neuron Differentiation Regulation Of Gliogenesis Glial Cell Differentiation Negative Regulation Of Neuron Projection Development Intracellular Membrane-bounded Organelle Negative Regulation Of Nervous System Development Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Negative Regulation Of Neurogenesis Neuron Migration Adult Behavior Axonogenesis Negative Regulation Of Cell Projection Organization Locomotory Behavior
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