DAB1 and PCDH18

Number of citations of the paper that reports this interaction (PubMedID 11716507)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DAB1	PCDH18
Description		DAB adaptor protein 1	protocadherin 18
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Adaptor Activity	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Neuron Migration Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Hippocampus Development Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Regulation Of Synapse Maturation Motor Neuron Migration Lateral Motor Column Neuron Migration Radial Glia-guided Pyramidal Neuron Migration	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Brain Development
Pathways		Reelin signalling pathway
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age at first sexual intercourse ( 34211149) Alzheimer's disease progression score ( 29860282) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Cardiac troponin-I levels ( 31014085) Coronary artery disease ( 29472232) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Immune reponse to smallpox (secreted IL-10) ( 22610502) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Kawasaki disease ( 21221998) Lateral orbital frontal cortex volume ( 31530798) Logical memory (delayed recall) in normal cognition ( 29274321) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Pubertal anthropometrics ( 23449627) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196) White matter hyperintensities in ischemic stroke ( 26674333)	Adult body size ( 32376654) Adverse response to radiation therapy ( 23719583) Body size at age 10 ( 32376654) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Essential hypertension (time to event) ( 32589924) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Obesity-related traits ( 23251661) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) P wave terminal force ( 28794112) Refractive error ( 32231278) Retinopathy in non-diabetics ( 23393555) Temperament ( 22832960) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		76 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488	2 interacting genes: DAB1 UBQLN1
Entrez ID		1600	54510
HPRD ID		04582	12205
Ensembl ID		ENSG00000173406	ENSG00000189184
Uniprot IDs		O75553	Q9HCL0
PDB IDs			6VFR
Enriched GO Terms of Interacting Partners?		Reelin-mediated Signaling Pathway Receptor Complex Layer Formation In Cerebral Cortex Cellular Response To Growth Factor Stimulus Low-density Lipoprotein Particle Receptor Activity Response To Growth Factor Cell Surface Receptor Signaling Pathway Clathrin-coated Pit Enzyme-linked Receptor Protein Signaling Pathway Cargo Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Dendrite Development Neuron Projection Morphogenesis Very-low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Endocytosis Regulation Of Macromolecule Metabolic Process Apolipoprotein Binding Hippocampus Development ErbB-3 Class Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Forebrain Development Regulation Of Gene Expression Cerebral Cortex Development System Development Positive Regulation Of Protein Catabolic Process In The Vacuole Negative Regulation Of Leukocyte Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Postsynaptic Specialization Organization Negative Regulation Of Immune System Process Ventral Spinal Cord Development Anatomical Structure Morphogenesis Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Integrin-mediated Signaling Pathway Integrin Complex Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Activation Regulation Of Synapse Organization Receptor Tyrosine Kinase Binding Nervous System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Glial Cell Development Protein Binding Regulation Of Cell Motility Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Regulation Of Lysosomal Protein Catabolic Process	Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Radial Glia-guided Pyramidal Neuron Migration Negative Regulation Of Astrocyte Differentiation Cell Migration In Hindbrain Golgi Localization Perinuclear Region Of Cytoplasm Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Motor Neuron Migration Aggrephagy Regulation Of Toll-like Receptor 3 Signaling Pathway Layer Formation In Cerebral Cortex Anatomical Structure Arrangement Positive Regulation Of ERAD Pathway Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Glial Cell Differentiation Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Regulation Of Synapse Maturation Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Astrocyte Differentiation Cerebral Cortex Cell Migration Astrocyte Differentiation Adult Walking Behavior Aggresome Walking Behavior Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Gliogenesis Telencephalon Cell Migration Dendrite Development Forebrain Cell Migration Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Axonogenesis Negative Regulation Of Calcium Ion Transport Autophagosome Maturation Negative Regulation Of Signal Transduction Proteasome Complex Negative Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signaling
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