DAB1 and SOCS7

Number of citations of the paper that reports this interaction (PubMedID 24210661)
46

Data Source:
BioGRID (enzymatic study)

		DAB1	SOCS7
Description		DAB adaptor protein 1	suppressor of cytokine signaling 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Neuron Migration Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Hippocampus Development Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Regulation Of Synapse Maturation Motor Neuron Migration Lateral Motor Column Neuron Migration Radial Glia-guided Pyramidal Neuron Migration	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration
Pathways		Reelin signalling pathway
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age at first sexual intercourse ( 34211149) Alzheimer's disease progression score ( 29860282) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Cardiac troponin-I levels ( 31014085) Coronary artery disease ( 29472232) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Immune reponse to smallpox (secreted IL-10) ( 22610502) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Kawasaki disease ( 21221998) Lateral orbital frontal cortex volume ( 31530798) Logical memory (delayed recall) in normal cognition ( 29274321) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Pubertal anthropometrics ( 23449627) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196) White matter hyperintensities in ischemic stroke ( 26674333)	Ovarian cancer ( 23535730)
Interacting Genes		76 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488	25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1
Entrez ID		1600	30837
HPRD ID		04582	12299
Ensembl ID		ENSG00000173406	ENSG00000274211
Uniprot IDs		O75553	A0A5F9YLF9 O14512
PDB IDs
Enriched GO Terms of Interacting Partners?		Reelin-mediated Signaling Pathway Receptor Complex Layer Formation In Cerebral Cortex Cellular Response To Growth Factor Stimulus Low-density Lipoprotein Particle Receptor Activity Response To Growth Factor Cell Surface Receptor Signaling Pathway Clathrin-coated Pit Enzyme-linked Receptor Protein Signaling Pathway Cargo Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Dendrite Development Neuron Projection Morphogenesis Very-low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Endocytosis Regulation Of Macromolecule Metabolic Process Apolipoprotein Binding Hippocampus Development ErbB-3 Class Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Forebrain Development Regulation Of Gene Expression Cerebral Cortex Development System Development Positive Regulation Of Protein Catabolic Process In The Vacuole Negative Regulation Of Leukocyte Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Postsynaptic Specialization Organization Negative Regulation Of Immune System Process Ventral Spinal Cord Development Anatomical Structure Morphogenesis Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Integrin-mediated Signaling Pathway Integrin Complex Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Activation Regulation Of Synapse Organization Receptor Tyrosine Kinase Binding Nervous System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Glial Cell Development Protein Binding Regulation Of Cell Motility Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Regulation Of Lysosomal Protein Catabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?