DAB1 and DAB2IP

Number of citations of the paper that reports this interaction (PMID 11812785)
24

Data Source:
HPRD (in vivo, in vitro)

		DAB1	DAB2IP
Gene Name		Dab, reelin signal transducer, homolog 1 (Drosophila)	DAB2 interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Endocytic Vesicle Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Neuronal Cell Body Membrane Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Extracellular Vesicular Exosome Parallel Fiber
	Molecular Function	Phosphatidylinositol 3-kinase Binding	Ras GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Protein Complex Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Phosphatidylinositol 3-kinase Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Transformed Cell Apoptotic Process Inflammatory Response Response To Unfolded Protein Cell Cycle I-kappaB Phosphorylation Activation Of JUN Kinase Activity Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of ARF GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Ras GTPase Activity Tube Formation Negative Regulation Of Catenin Import Into Nucleus Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Reelin-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Cycle Arrest Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cyclin Catabolic Process Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)	Abdominal aortic aneurysm ( 20622881) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Heart rate ( 23534349) Periodontal microbiota ( 22699663) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488	5 interactors: AKT1 DAB1 DAB2 MAP3K5 YWHAQ
Entrez ID		1600	153090
HPRD ID		04582	09903
Ensembl ID		ENSG00000173406	ENSG00000136848
Uniprot IDs		O75553	Q5VWQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Programmed Cell Death Positive Regulation Of Proteolysis Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Death Regulation Of Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Localization To Plasma Membrane Regulation Of Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Death Regulation Of JUN Kinase Activity JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion
Tagcloud ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical	al chronic cytoplasm dependent di et induces inflammation interacts issue jnk kb link minin mutant mutp53 nf p53 profile progression signaling suppressor tnf transcriptional tumor tumorigenic via
Tagcloud (Difference) ?		assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical	al chronic cytoplasm dependent di et induces inflammation interacts issue jnk kb link minin mutant mutp53 nf p53 profile progression signaling suppressor tnf transcriptional tumor tumorigenic via
Tagcloud (Intersection) ?