DAB1 and ITGB7

Number of citations of the paper that reports this interaction (PubMedID 12606711)
45

Data Source:
HPRD (in vitro)

		DAB1	ITGB7
Description		DAB adaptor protein 1	integrin subunit beta 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Signaling Adaptor Activity	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Neuron Migration Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Small GTPase-mediated Signal Transduction Nervous System Development Axonogenesis Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Hippocampus Development Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Regulation Of Synapse Maturation Motor Neuron Migration Lateral Motor Column Neuron Migration Radial Glia-guided Pyramidal Neuron Migration	Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling T Cell Migration Cell-cell Adhesion
Pathways		Reelin signalling pathway	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs			R1295 Vedolizumab Etrolizumab
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age at first sexual intercourse ( 34211149) Alzheimer's disease progression score ( 29860282) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Cardiac troponin-I levels ( 31014085) Coronary artery disease ( 29472232) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Immune reponse to smallpox (secreted IL-10) ( 22610502) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Kawasaki disease ( 21221998) Lateral orbital frontal cortex volume ( 31530798) Logical memory (delayed recall) in normal cognition ( 29274321) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Pubertal anthropometrics ( 23449627) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196) White matter hyperintensities in ischemic stroke ( 26674333)	Obesity-related traits ( 23251661) Type 1 diabetes ( 34127860)
Interacting Genes		76 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488	15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1
Entrez ID		1600	3695
HPRD ID		04582	00948
Ensembl ID		ENSG00000173406	ENSG00000139626
Uniprot IDs		O75553	P26010
PDB IDs			2BRQ 3V4P 3V4V 8ZJF
Enriched GO Terms of Interacting Partners?		Reelin-mediated Signaling Pathway Receptor Complex Layer Formation In Cerebral Cortex Cellular Response To Growth Factor Stimulus Low-density Lipoprotein Particle Receptor Activity Response To Growth Factor Cell Surface Receptor Signaling Pathway Clathrin-coated Pit Enzyme-linked Receptor Protein Signaling Pathway Cargo Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Dendrite Development Neuron Projection Morphogenesis Very-low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Endocytosis Regulation Of Macromolecule Metabolic Process Apolipoprotein Binding Hippocampus Development ErbB-3 Class Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Forebrain Development Regulation Of Gene Expression Cerebral Cortex Development System Development Positive Regulation Of Protein Catabolic Process In The Vacuole Negative Regulation Of Leukocyte Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Postsynaptic Specialization Organization Negative Regulation Of Immune System Process Ventral Spinal Cord Development Anatomical Structure Morphogenesis Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Integrin-mediated Signaling Pathway Integrin Complex Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Activation Regulation Of Synapse Organization Receptor Tyrosine Kinase Binding Nervous System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Glial Cell Development Protein Binding Regulation Of Cell Motility Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Regulation Of Lysosomal Protein Catabolic Process	Cell-cell Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Regulation Of Cell Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Protein Kinase C Signaling Positive Regulation Of Protein Import Into Nucleus Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Integrin Binding Cell Migration Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Receptor Clustering Cell-cell Adhesion Mediated By Integrin Leukocyte Cell-cell Adhesion Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport B Cell Activation Cell Motility Perinuclear Region Of Cytoplasm Extracellular Exosome Regulation Of Protein Transport Integrin Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cellular Response To Insulin Stimulus Enzyme Activator Activity Positive Regulation Of Intracellular Protein Transport Cell Adhesion Molecule Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Plasma Membrane Protein Activation Cascade Positive Regulation Of Cell Motility Protein Localization To Membrane Cadherin Binding Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility
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