MARK4 and HGS

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		MARK4	HGS
Gene Name		MAP/microtubule affinity-regulating kinase 4	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Neuron Projection	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau-protein Kinase Activity	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Nervous System Development Positive Regulation Of Programmed Cell Death	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		28 interactors: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NL ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP RPTOR STK11 TUBA4A TUBB TUBG1 UBC YWHAB YWHAH YWHAZ	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		57787	9146
HPRD ID		09402	05085
Ensembl ID		ENSG00000007047	ENSG00000185359
Uniprot IDs		Q96L34	O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Cellular Localization G2/M Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Establishment Of Localization In Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Golgi Localization Regulation Of Cell Projection Organization Positive Regulation Of Transport Cell Cycle Cell Cycle Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Development Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Microtubule Cytoskeleton Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Cell Morphogenesis Response To Stimulus Microtubule-based Process Regulation Of Apoptotic Process Cellular Response To Organic Substance Cellular Component Assembly Establishment Of Golgi Localization Neuron Differentiation Cytoskeleton Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Axonogenesis Regulation Of Cellular Component Organization Neuron Projection Development Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Death Generation Of Neurons Membrane Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Glucocorticoid Receptor Signaling Pathway Neurogenesis	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?