MARK4 and MED20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MARK4	MED20
Description		microtubule affinity regulating kinase 4	mediator complex subunit 20
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection	Nucleus Nucleoplasm Mediator Complex Protein-containing Complex Core Mediator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Skeletal Muscle Cell Differentiation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Anchoring of the basal body to the plasma membrane	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Granulocyte count ( 27863252) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 27863252 32888494)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 23263863 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)
Interacting Genes		32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ	18 interacting genes: ANKS1A CD300C CEBPB CYB5R2 ERP27 ESR1 ESR2 GABPB1 MARK4 MED18 MED29 MED8 PIH1D2 POLR1B PSORS1C2 TRIM69 UBC YY1
Entrez ID		57787	9477
HPRD ID		09402	15638
Ensembl ID		ENSG00000007047	ENSG00000124641
Uniprot IDs		Q96L34	B3KUJ9 Q9H944
PDB IDs		5ES1 8XFL	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development	RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Core Mediator Complex Nuclear Estrogen Receptor Activity Mediator Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Protein-DNA Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Estrogen Response Element Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Transcription Coregulator Activity Negative Regulation Of MiRNA Transcription Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Estradiol Stimulus Sequence-specific DNA Binding Cellular Response To Interleukin-1 Protein-containing Complex Assembly Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Granuloma Formation C/EBP Complex Immunoglobulin Heavy Chain V-D-J Recombination Nucleologenesis T-helper 1 Cell Activation Transcription Cis-regulatory Region Binding CHOP-C/EBP Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Macromolecule Biosynthetic Process Prostate Epithelial Cord Elongation Regulation Of MiRNA Transcription Positive Regulation Of Nitric-oxide Synthase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein-containing Complex Organization Response To Prostaglandin F
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