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MARK4
Description
microtubule affinity regulating kinase 4
Image
GO Annotations
Cellular Component
Gamma-tubulin Complex
Cytoplasm
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Microtubule Cytoskeleton
Dendrite
Midbody
Ciliary Basal Body
Cell Projection
Neuron Projection
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Cytoskeletal Anchor Activity
Kinase Activity
Transferase Activity
Gamma-tubulin Binding
Ubiquitin Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Protein Phosphorylation
Nervous System Development
Cell Projection Organization
Intracellular Signal Transduction
Positive Regulation Of Programmed Cell Death
Cilium Organization
Positive Regulation Of Cilium Assembly
Positive Regulation Of Cell Cycle
Regulation Of Centrosome Cycle
Microtubule Polymerization
Cell Division
Cilium Disassembly
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Protein Localization To Centrosome
Pathways
Anchoring of the basal body to the plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Advanced age-related macular degeneration (
26691988
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Basophil count (
32888494
)
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x age interaction (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Granulocyte count (
27863252
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
L1-L4 bone mineral density x serum urate levels interaction (
34046847
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
27863252
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Neutrophil percentage of white cells (
32888494
)
Parental longevity (father's attained age) (
29227965
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
27863252
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum eosinophil basophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Triglyceride levels (
32203549
)
White blood cell count (
27863252
32888494
)
Interacting Genes
32 interacting genes:
AKT1
APLNR
CDC42
HGS
HNRNPK
HPS6
KHDRBS3
KRT31
KRT40
MAP2
MAP4
MAPT
MED20
MTUS2
NEDD4
NLRP3
NOTCH2NLA
ODF2
PARD6A
PNMA1
PRKCG
PRKCI
PRNP
PTBP1
RPTOR
STK11
TUBA4A
TUBB
TUBG1
YWHAB
YWHAH
YWHAZ
Entrez ID
57787
HPRD ID
09402
Ensembl ID
ENSG00000007047
Uniprot IDs
Q96L34
PDB IDs
5ES1
8XFL
Enriched GO Terms of Interacting Partners
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Microtubule Cytoskeleton
Protein Domain Specific Binding
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Projection Organization
Phosphoserine Residue Binding
Microtubule
Regulation Of Cellular Component Organization
Cytosol
Cytoskeleton
Structural Molecule Activity
Regulation Of Transport
Golgi Localization
Organelle Organization
Cytoplasm
Regulation Of Cellular Localization
Tubulin Binding
Regulation Of Cell Communication
Regulation Of Signaling
Cilium
Intracellular Protein Localization
GTP-dependent Protein Binding
Cytoskeleton Organization
Extracellular Exosome
Regulation Of Neuron Projection Development
Positive Regulation Of Transport
Regulation Of Synapse Organization
Negative Regulation Of Cell Projection Organization
Positive Regulation Of Vesicle Transport Along Microtubule
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Supramolecular Fiber Organization
Regulation Of Signal Transduction
Regulation Of Protein Localization
Regulation Of TORC1 Signaling
Neuron Projection
Main Axon
Nuclear Receptor-mediated Corticosteroid Signaling Pathway
Structural Constituent Of Cytoskeleton
Protein Targeting
PAR Polarity Complex
Enzyme Binding
Regulation Of Cell Growth
Microtubule-based Process
Establishment Of Golgi Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Microtubule Binding
Regulation Of Cell Development
Regulation Of Organelle Transport Along Microtubule
Transmembrane Transporter Binding
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Nervous System Development
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